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The Effect of Diabetes on Performance and Metabolism of Rat Hearts
It is indicated that streptozotocin diabetes in rats results in abnormal myocardial performance and is not correctable by the provision of high glucose plus insulin in the perfusion medium. Expand
Depressed cardiac sarcoplasmic reticular function from diabetic rats.
Calcium uptake by isolated sarcoplasmic reticulum in the absence of oxalate were significantly lower in preparations from hearts of diabetic males and females than from controls, which may partially explain the abnormalities in contraction and relaxation previously observed in Hearts of diabetic animals. Expand
The Effects of Gonadectomy on Left Ventricular Function and Cardiac Contractile Proteins in Male and Female Rats
It is suggested that the sex hormones have cardioregulatory properties, but it remains uncertain whether their effect is exerted during or after maturation. Expand
Effects of gonadectomy and hormonal replacement on rat hearts.
Cardiac performance in perfused hearts, as measured by stroke work, ejection fraction, fractional shortening and mean velocity of circumferential fiber shortening, was decreased inMGX but was slightly increased in MGX + T, while papillary muscle studies showed increases in time to peak tension and one-half relaxation in MGx, but these were decreased in MG X + T. Expand
Cardiac adaptations to chronic exercise.
Alterations in gene expression in the rat heart after chronic pathological and physiological loads.
The relative amounts of the mRNAs encoding cardiac sarcoplasmic reticular calcium ATPase, cardiac and skeletal troponin I, atrial natriuretic factor, and myosin light chain 1 in the hearts of rats that had been subjected to either conditioning by swimming, to renovascular hypertension, or to the combined stimulus for 6 weeks are investigated. Expand
Reversibility of Diabetic Cardiomyopathy with Insulin in Rats
This study confirms that this model of a cardiomyopathy is not a result of streptozotocin-induced cardiac toxicity, and indicates that depressed thyroid hormone levels in diabetic rats are not responsible for the mechanical changes observed. Expand
Myocardial uptake and fractional distribution of palmitate-1 C14 by the ischemic dog heart.
It is suggested that the histologic evidence of myocardial lipid accumulation noted, in association with hypoxia, is due to a stimulation of triglyceride synthesis from exogenous sources of FFA via the phosphatidic acid pathway. Expand
Effects of age on mechanical and electrical performance of rat myocardium.
Time to peak shortening increased, whereas peak velocity of muscle shortening decreased from 3 to 24 mo of age, which may help to explain the contractile modifications during aging. Expand