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Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and
TLDR
A systematic review and a meta-analysis suggest that the addition of r-hLH to r- hFSH may be beneficial for women with POR and there is a relative increase in the clinical pregnancy rates of 9% in the overall population and 30% in poor responders.
Patient experience with follitropin alfa prefilled pen versus previously used injectable gonadotropins for ovulation induction in oligoanovulatory women
TLDR
In this open-label, non-comparative study, patients undergoing OI preferred administering gonadotropins using the follitropin alfa prefilled pen compared to their prior use of vials/ampoules and a syringe.
Recombinant human follicle-stimulating hormone produces more oocytes with a lower total dose per cycle in assisted reproductive technologies compared with highly purified human menopausal
TLDR
As the largest meta-analysis published to date on this subject, treatment with human menopausal gonadotrophins is characterized by fewer oocytes and a higher total dose, and meta-analytic results are more sensitive when these variables are considered.
The redesigned follitropin α pen injector for infertility treatment
TLDR
The availability of an improved injection device for the delivery of follitropin α used during infertility treatment cycles of ovulation induction and assisted reproductive technology offers patients and healthcare professionals new treatment administration options.
Patient evaluation of the redesigned follitropin alfa pen injector
TLDR
The redesigned GONAL-f (follitropin alfa) pen injector was considered easy to learn to use and easy to use, particularly setting the dose and reading the number on the dial.
Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders
TLDR
The primary and secondary efficacy endpoints were comparable between treatment groups and the safety profile of both treatment regimens was favourable, with r-hFSH/r-hLH associated with a higher live birth rate for patients with moderate or severe POR, whereas r- hFSH was associated with an higher liveBirth rate for those with mild POR.
A comparison of menotropin, highly-purified menotropin and follitropin alfa in cycles of intracytoplasmic sperm injection
TLDR
A retrospective analysis of 865 consecutive intracytoplasmic sperm injection (ICSI) cycles of controlled ovarian hyperstimulation (COH) compared the clinical efficacy of three gonadotropins for ovarian stimulation after pituitary down-regulation, finding markedly lower doses of r-hFSH were required compared with hMG or HP-hMG.
Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders
P. Humaidan*, W. Chin, D. Rogoff, T. D’Hooghe, S. Longobardi, J. Hubbard, and J. Schertz on behalf of the ESPART Study Investigators The Fertility Clinic, Skive Regional Hospital, Skive, Denmark
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