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Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors.
- G. Wasner, J. Schattschneider, A. Binder, R. Baron
- Biology, MedicineBrain : a journal of neurology
- 1 May 2004
Although cold hyperalgesia is a frequent symptom in patients with neuropathic pain, it is poorly understood. We investigated the mechanisms of cold pain by studying the effect of menthol on pain,…
The motor system shows adaptive changes in complex regional pain syndrome.
- C. Maihöfner, R. Baron, J. Schattschneider
- Psychology, BiologyBrain : a journal of neurology
- 1 October 2007
The results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS.
Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value.
- G. Wasner, J. Schattschneider, K. Heckmann, C. Maier, R. Baron
- MedicineBrain : a journal of neurology
- 1 March 2001
It is suggested that, in CRPS I, unilateral inhibition of sympathetic vasoconstrictor neurones leads to a warmer affected limb in the acute stage, whereas sympathetic activity is still depressed.
Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study
Complex regional pain syndrome – diagnostic, mechanisms, CNS involvement and therapy
Though there is no diagnostic gold standard, careful clinical evaluation and additional test procedures should lead to an adequate diagnosis, an early diagnosis and an interdisciplinary approach are important for optimal and successful treatment.
Postherpetic neuralgia: Topical lidocaine is effective in nociceptor–deprived skin
- G. Wasner, A. Kleinert, A. Binder, J. Schattschneider, R. Baron
- Medicine, BiologyJournal of Neurology
- 23 March 2005
Topical lidocaine is effective in postherpetic neuralgia (PHN) even if the skin was completely deprived of nociceptor–deprived skin, and subgroup analysis revealed that patients with impairment of nOCICEptor function had significantly greater pain reduction under lidocane vs placebo.
Harlequin syndrome - one face of many etiologies
Harlequin syndrome following a lesion of the preganglionic sympathetic efferents, caused by neurovascular compression of the sympathetic chain between the stellate and superior cervical ganglion brought about by an elongated inferior thyroid artery is diagnosed.
Idiopathic restless legs syndrome: abnormalities in central somatosensory processing.
- J. Schattschneider, A. Bode, G. Wasner, A. Binder, G. Deuschl, R. Baron
- Medicine, BiologyJournal of neurology
- 9 September 2005
The frequency of thermal hypaesthesia in a large population of secondary and idiopathic restless legs syndrome patients was determined to differentiate between a peripheral and central disturbance of somatosensory processing and to correlate these findings with the clinical manifestation of the disease.
Histamine-induced itch converts into pain in neuropathic hyperalgesia
- R. Baron, K. Schwarz, A. Kleinert, J. Schattschneider, G. Wasner
- Medicine, BiologyNeuroreport
- 16 November 2001
Physiologically, itch and pain are transmitted in separate specific peripheral C-units and central afferent pathways and in neuropathies irritable nociceptors may express histamine receptors or induce central sensitization to histaminergic stimuli so that itch converts into pain.