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Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome.
TLDR
It is confirmed that psychiatric comorbidities are common among individuals with TS, demonstrates that most comor bidities begin early in life, and indicates that certain comorbiities may be mediated by the presence of comorbrid OCD or ADHD.
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A structural variation reference for medical and population genetics
TLDR
A large empirical assessment of sequence-resolved structural variants from 14,891 genomes across diverse global populations in the Genome Aggregation Database (gnomAD) provides a reference map for disease-association studies, population genetics, and diagnostic screening.
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Population prevalence of Tourette syndrome: A systematic review and meta‐analysis
TLDR
Study sample size, which is likely a proxy for case assessment method, and the use of DSM‐IV‐TR diagnostic criteria are the major sources of heterogeneity across studies, which refines the population prevalence estimate of TS in children to be 0.3% to 0.9%.
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Association of the SLC1A1 glutamate transporter gene and obsessive‐compulsive disorder
TLDR
A significant association between the SLC1A1 glutamate transporter gene and OCD is identified in a haplotype overlapping with that recently reported.
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Prevalence of Tourette Syndrome and Chronic Tics in the Population-Based Avon Longitudinal Study of Parents and Children Cohort
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The genetics of Tourette syndrome: a review.
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Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort†
TLDR
This study supports previously reported relationships between Tourette syndrome/chronic tic disorder and prenatal alcohol exposure, and identifies additional previously unexplored potential prenatal risk factors.
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Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture
TLDR
The results indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.
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Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis
TLDR
A meta-analysis from two independent OCD consortia, investigating a total of 2688 individuals of European ancestry with OCD and 7037 genomically matched controls, concludes that the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD.
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Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.
TLDR
The data suggest that the U2 tandem repeat, once established in the primate lineage, contained sequence elements favoring perpetuation and concerted evolution of the array in situ, despite a pericentric inversion in chimpanzee, a reciprocal translocation in gorilla and a paracentric inversions in orang utan.
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