Normal biochemical and hematological values in New Zealand white rabbits.
- C. D. Hewitt, D. Innes, J. Savory, M. Wills
- Medicine, BiologyClinical Chemistry
- 1 August 1989
Animal model systems are used extensively for experimental in vivo studies and biochemical and hematological blood variables were measured by methods available in routine service laboratory, and ranges were reported.
Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2.
- W. Roberts, L. Moulton, N. Rifai
- MedicineClinical Chemistry
- 2001
Nine high-sensitivity CRP methods from Dade Behring, Daiichi, Denka Seiken, Diagnostic Products Corporation, Iatron, Kamiya, Olympus, Roche, and Wako were evaluated for limit of detection, linearity, precision, prozone effect, and comparability with samples from 388 apparently healthy individuals.
The significance of environmental factors in the etiology of Alzheimer's disease.
- W. Grant, A. Campbell, R. Itzhaki, J. Savory
- MedicineJournal of Alzheimer's Disease
- 2002
Diet, aluminum, and viral infections may increase the prevalence of AD by eliciting inflammation, which may cause the neurological damage that results in AD.
Lithium inhibits aluminum‐induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl‐2 decrease, Bax elevation and caspase‐3 activation
- O. Ghribi, M. Herman, Natalie K Spaulding, J. Savory
- Biology, ChemistryJournal of Neurochemistry
- 1 July 2002
It is proposed that the neuroprotective effect of lithium involves the modulation of apoptosis‐regulatory proteins present in the subcellular organelles of rabbit brain.
Transferrin binding of Al3+ and Fe3+.
- R. Martin, J. Savory, S. Brown, R. Bertholf, M. Wills
- Chemistry, BiologyClinical Chemistry
- 1 March 1987
Quantitative studies demonstrate that the protein transferrin (iron-free) is the strongest Al3+ binder in blood plasma and stability constants are weaker than expected, suggesting that the significantly smaller Al3+.
Can the controversy of the role of aluminum in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered?
- J. Savory, C. Exley, I. Wakayama
- BiologyJournal of Toxicology and Environmental Health…
- 30 August 1996
The key questions that must be answered before it can be asserted that Al possesses causal relationship to Alzheimer's disease, are addressed and are addressed in this present discussion.
MPP+ Induces the Endoplasmic Reticulum Stress Response in Rabbit Brain Involving Activation of the ATF‐6 and NF‐κB Signaling Pathways
- O. Ghribi, M. Herman, P. Pramoonjago, J. Savory
- Biology, ChemistryJournal of Neuropathology and Experimental…
- 1 November 2003
It is demonstrated that MPP+ in a dose-dependent manner induces the loss of tyrosine hydroxylase activity, oxidative DNA damage, and activation of the endoplasmic reticulum stress response, which correlates with the activation of caspase-3 and of c-Jun N-terminal kinase (JNK) kinase.
Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release.
- K. Griffioen, O. Ghribi, N. Fox, J. Savory, D. Dewitt
- BiologyNeurotoxicology
- 1 September 2004
The clinical biochemistry of aluminum.
- S. W. King, J. Savory, M. Wills
- BiologyCritical reviews in clinical laboratory sciences
- 1 May 1981
The many papers that have been published concerning aluminum, DES, and Alzheimer's Disease make a strong case for linking elevated tissue aluminum content with these conditions, but conclusive evidence to support this theory has not been published.
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