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A blast from the past: clearance of apoptotic cells regulates immune responses
Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion ofExpand
Resolution of inflammation: the beginning programs the end
Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways. Expand
Corpse clearance defines the meaning of cell death
Appoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes allow scavenger cells to confer meaning upon cell death. Expand
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.
Changes in the senescent neutrophil that are associated with their recognition by macrophages are the subject of this investigation, and these processes may represent a mechanism for the removal of neutrophils during inflammation that also serves to limit the degree of tissue injury. Expand
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.
Newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution are indicated. Expand
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
It is shown that the CDK inhibitor R-roscovitine markedly enhances resolution of established neutrophil-dependent inflammation in carrageenan-elicited acute pleurisy, bleomycin-induced lung injury, and passively induced arthritis in mice. Expand
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo
These results constitute the first demonstration of an impairment in the phagocytosis of apoptotic cells by macrophages in vivo in a mammalian system and may explain the link between hereditary complement deficiency and the development of SLE. Expand
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells
It is demonstrated that AC exert a profound influence on an adaptive immune response through the generation of CD19+ regulatory B cells, which in turn are able to influence the cytokine profile of antigen-specific effector T cells. Expand
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
It is reported that macrophage recognition of apoptotic cells (both neutrophils and lymphocytes) is mediated by the vitronectin receptor, a heterodimer belonging to the β3 or cytoadhesin family of the integrins. Expand
Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.
The results suggest that the mechanism by which apoptotic cells are recognized and phagocytosed by macrophages is determined by the subpopulation of macrophage studied. Expand