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Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
TLDR
These guidelines supersede the prior 2007 guidelines and 2009 updates and support the overarching concept of stroke systems of care and detail aspects of stroke care from patient recognition; emergency medical services activation, transport, and triage; through the initial hours in the emergency department and stroke unit.
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Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials
TLDR
Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location, and will have global implications on structuring systems of care to provide timely treatment.
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Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.
TLDR
In patients receiving intravenous t-PA for acute ischemic stroke, thrombectomy with the use of a stent retriever within 6 hours after onset improved functional outcomes at 90 days.
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Time Is Brain—Quantified
  • J. Saver
  • Medicine, Biology
    Stroke
  • 1 January 2006
TLDR
Quantitative estimates of the pace of neural circuitry loss in human ischemic stroke emphasize the time urgency of stroke care.
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The Impact of Recanalization on Ischemic Stroke Outcome: A Meta-Analysis
TLDR
Recanalization is strongly associated with improved functional outcomes and reduced mortality and is an appropriate biomarker of therapeutic activity in early phase trials of thrombolytic treatment in acute ischemic stroke.
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A trial of imaging selection and endovascular treatment for ischemic stroke.
TLDR
A favorable penumbral pattern on neuroimaging did not identify patients who would differentially benefit from endovascular therapy for acute ischemic stroke, nor was embolectomy shown to be superior to standard care.
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Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
TLDR
Among patients with acute stroke who had last been known to be well 6 to 24 hours earlier and who had a mismatch between clinical deficit and infarct, outcomes for disability at 90 days were better with thrombectomy plus standard care than with standard care alone.
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Closure of patent foramen ovale versus medical therapy after cryptogenic stroke.
TLDR
There was no significant benefit associated with closure of a patent foramen ovale in adults who had had a cryptogenic ischemic stroke, however, closure was superior to medical therapy alone in the prespecified per-protocol and as-treated analyses, with a low rate of associated risks.
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Safety and Efficacy of Mechanical Embolectomy in Acute Ischemic Stroke: Results of the MERCI Trial
TLDR
A novel endovascular embolectomy device can significantly restore vascular patency during acute ischemic stroke within 8 hours of stroke symptom onset and provides an alternative intervention for patients who are otherwise ineligible for thrombolytics.
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Long‐Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke
TLDR
Among adults who had had a cryptogenic ischemic stroke, closure of a PFO was associated with a lower rate of recurrent isChemic strokes than medical therapy alone during extended follow‐up.
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