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CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration
CD44 is a cell surface receptor for hyaluronate, a component of the extracellular matrix (ECM). Although CD44 has been implicated in tumor invasion and metastasis, the molecular mechanisms remain to… Expand
Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo.
- T. Mukhopadhyay, J. Sasaki, R. Ramesh, J. Roth
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 September 2002
We have found that mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. In this study, MZ arrested cells at the… Expand
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
- J. Sasaki, R. Ramesh, S. Chada, Y. Gomyo, J. Roth, T. Mukhopadhyay
- Medicine, Biology
- Molecular cancer therapeutics
- 1 November 2002
Microtubules have a critical role in cell division, and consequently various microtubule inhibitors have been developed as anticancer drugs. In this study, we assess mebendazole (MZ), a… Expand
Synergistic Tumor Suppression by Coexpression of FHIT and p53 Coincides with FHIT-Mediated MDM2 Inactivation and p53 Stabilization in Human Non-Small Cell Lung Cancer Cells
Aberrations of the tumor suppressor genes FHIT and p53 are frequently associated with a wide range of human cancers, including lung cancer. We studied the combined effects of FHIT and p53 proteins on… Expand
5-aza-2′-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells
Treating lung cancer cell lines using low-dose 5-aza-2′-deoxycytidine (DAC) caused an accumulation of procaspase-9 through mRNA upregulation, but the cells did not undergo apoptosis. However, when… Expand
Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells.
- Asumi Hira, H. Watanabe, +6 authors H. Saito
- Biology, Medicine
- Biochemical pharmacology
- 15 February 2008
Amrubicin is a completely synthetic 9-aminoanthracycline agent for the treatment of lung cancer in Japan. The cytotoxicity of C-13 hydroxy metabolite, amrubicinol, is 10 to 100 times greater than… Expand
Expression of constitutively activated EGFRvlll in non‐small cell lung cancer
The epidermal growth factor receptor (EGFR) variant type III (variously called EGFRvlll, de2–7 EGFR or ΔGFR) has an in‐frame deletion of the extracellular domain and is found in numerous types of… Expand
Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein
We have cloned a cDNA for a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein, termed NE-dlg (neuronal and endocrine dlg). Northern blot analysis revealed that the gene… Expand
Methylprednisolone Accelerates the Resolution of Glomerulonephritis by Sensitizing Mesangial Cells to Apoptosis
- K. Maruyama, N. Kashihara, +7 authors H. Makino
- Nephron Experimental Nephrology
- 31 August 2001
Glucocorticoid has long been used to treat patients with glomerulonephritis because it ameliorates mesangial cell proliferation and proteinuria, in part by suppressing nuclear factor-kappa B (NF-ĸB)… Expand
The confirmation of norethindrone aromatization in primary human hepatocytes by the Vitafiber-II cell culture system.
- T. Yamamoto, J. Kitawaki, +6 authors H. Okada
- Chemistry, Medicine
- Nihon Sanka Fujinka Gakkai zasshi
A portion of norethindrone (17 alpha-ethynyl-19-nortestosterone) was confirmed to be aromatized to ethynyl estradiol (17 alpha-ethynyl estradiol) in primary human hepatocytes cultured using the… Expand