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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Cells, the basic units of biological structure and function, vary broadly in type and state. Single-cell genomics can characterize cell identity and function, but limitations of ease and scale haveExpand
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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins (together termed XFPs) were selectively expressed in neurons. All four XFPs labeled neurons in their entirety,Expand
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Development of the vertebrate neuromuscular junction.
We describe the formation, maturation, elimination, maintenance, and regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses. The NMJ forms in a series of stepsExpand
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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Do new synapses form in the adult cortex to support experience-dependent plasticity? To address this question, we repeatedly imaged individual pyramidal neurons in the mouse barrel cortex overExpand
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Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Detailed analysis of neuronal network architecture requires the development of new methods. Here we present strategies to visualize synaptic circuits by genetically labelling neurons with multiple,Expand
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Induction, assembly, maturation and maintenance of a postsynaptic apparatus
Key Points The neuromuscular junction (NMJ) is one of the best models to study the induction, assembly, maturation and maintenance of a postsynaptic apparatus. The three most widely appreciatedExpand
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MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
An Innervative Small RNA Amyotrophic lateral sclerosis (ALS) is a relentless disease characterized by progressive degeneration of motor neurons that control muscle movement, leading to muscle atrophyExpand
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Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
The development of chemical synapses is regulated by interactions between pre- and postsynaptic cells. At the vertebrate skeletal neuromuscular junction, the organization of an acetylcholine receptorExpand
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Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
During neuromuscular synapse formation, motor axons induce clustering of acetylcholine receptors (AChRs) in the muscle fiber membrane. The protein agrin, originally isolated from the basal lamina ofExpand
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Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
Patterns of gene expression can be used to characterize and classify neuronal types. It is challenging, however, to generate taxonomies that fulfill the essential criteria of being comprehensive,Expand
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