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Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease1
When exposed to a specific microenvironment, macrophages acquire either M1- or M2-polarized phenotypes associated with inflammation and tissue remodeling, respectively. Alveolar macrophages (AM)Expand
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Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
Background—Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene–environment interactions. Methods and Results—In a genome-wideExpand
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Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian andExpand
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Population genetic structure of the people of Qatar.
People of the Qatar peninsula represent a relatively recent founding by a small number of families from three tribes of the Arabian Peninsula, Persia, and Oman, with indications of African admixture.Expand
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Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), theExpand
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Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations
BackgroundPopulations of the Arabian Peninsula have a complex genetic structure that reflects waves of migrations including the earliest human migrations from Africa and eastern Asia, migrationsExpand
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Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
BACKGROUND Cardiac conduction, as assessed by electrocardiographic PR interval and QRS duration, is an important electrophysiological trait and a determinant of arrhythmia risk. OBJECTIVE We soughtExpand
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Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations.
An open question in the history of human migration is the identity of the earliest Eurasian populations that have left contemporary descendants. The Arabian Peninsula was the initial site of theExpand
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The Qatar genome: a population-specific tool for precision medicine in the Middle East
Reaching the full potential of precision medicine depends on the quality of personalized genome interpretation. In order to facilitate precision medicine in regions of the Middle East and NorthExpand
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Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia.
Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate are the major causes of morbidity and mortality in the developed world and are growing problems inExpand
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