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Centrosome amplification drives chromosomal instability in breast tumor development
TLDR
It is demonstrated that independent aspects of centrosome amplification correlate with chromosomal instability and loss of tissue differentiation and may be involved in tumor development and progression and that the centrosomes may be a potential target for cancer therapy.
Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity.
TLDR
Examining a set of 35 high grade human breast tumors shows that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosome of normal breast epithelial and stromal tissues.
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
TLDR
A mouse lacking Usp44 was engineered and it was found that USP44 regulated the mitotic checkpoint and prevented chromosome lagging, revealing a new role for the ubiquitin system in mitotic spindle regulation.
A nucleus-basal body connector in Chlamydomonas reinhardtii that may function in basal body localization or segregation
TLDR
It is suggested that fibrous connectors homologous to those described here for Chlamydomonas are general features of centriole-bearing eucaryotic cells, and that the nucleus-basal body union is important for accurate basal body localization within the cell and/or for accurate segregation of parental and daughter basal bodies at cell division.
Centrin plays an essential role in microtubule severing during flagellar excision in Chlamydomonas reinhardtii
TLDR
It is demonstrated that centrin-based fiber contraction plays a fundamental role in microtubule severing at the time of flagellar excision in Chlamydomonas.
Phosphorylation of Centrin during the Cell Cycle and Its Role in Centriole Separation Preceding Centrosome Duplication*
TLDR
It is suggested that centrin phosphorylation signals the separation of centrosomes at prophase and implicates centrinosphorylation in centriole separation that normally precedes centrosome duplication.
Centrin, centrosomes, and mitotic spindle poles.
Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles.
TLDR
It is suggested that centrin plays a role in centrosome separation at the time of mitosis and is a ubiquitous component of centrosomes and mitotic spindle poles of diverse organisms.
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