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Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.
This first multicentre study assessing the long-term efficacy of either STN or GPi stimulation shows a significant and substantial clinically important therapeutic benefit for at least 3-4 years in a large cohort of patients with severe Parkinson's disease.
The subthalamic nucleus in the context of movement disorders.
Both STN lesions and high frequency stimulation ameliorate the major motor symptoms of parkinsonism in humans and animal models of Parkinson's disease and reverse certain electrophysiological and metabolic consequences of dopamine depletion.
Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease.
- J. Saint-Cyr, L. Trépanier, R. Kumar, A. Lozano, A. Lang
- Psychology, MedicineBrain : a journal of neurology
- 1 October 2000
Bilateral STN DBS can have a negative impact on various aspects of frontal executive functioning, especially in patients older than 69 years, and the possible reversibility of these effects by turning the DBS off is examined.
A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease.
The suicide rate following subthalamic nucleus deep brain stimulation for Parkinson's disease was determined by conducting an international multicentre retrospective survey of movement disorder and surgical centres and factors associated with suicide attempts through a nested case-control study.
Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.
The findings suggest that the 'typical'/low dose (one to two tablets/session) chronic ecstasy-polydrug user might display a highly selective mild to marked loss of serotonin transporter in cerebral cortex/hippocampus in the range of that observed in Parkinson's disease.
Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow.
The validity of an outflow model in predicting the consequences of caudate nucleus dysfunction was supported and a small cluster of deficits emerged, interpreted as reflecting impairment in the ability to spontaneously generate efficient strategies when relying on self-directed task-specific planning.
Neuropsychological Outcome of GPi Pallidotomy and GPi or STN Deep Brain Stimulation in Parkinson's Disease
- L. Trépanier, R. Kumar, A. Lozano, A. Lang, J. Saint-Cyr
- Medicine, PsychologyBrain and Cognition
- 1 April 2000
The neuropsychological sequelae of posteroventral pallidotomy (PVP) and deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi) at 3/6 months postoperatively are highlighted.
Potentials recorded at the scalp by stimulation near the human subthalamic nucleus
Memory and learning in early Parkinson's disease: Evidence for a “frontal lobe syndrome”
Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imaging.
The anatomical localization of clinically effective electrode contacts provided in this study yields useful information for the postoperative programming of DBS electrodes.