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Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria
TLDR
Modifications of the Task Force Criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia represent a working framework to improve the diagnosis and management of this condition. Expand
Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria.
TLDR
The criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia have been modified to incorporate new knowledge and technology to improve diagnostic sensitivity, but with the important requisite of maintaining diagnostic specificity. Expand
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis.
TLDR
It is found that PGC-1 gene expression is induced in the mouse heart after birth and in response to short-term fasting, conditions known to increase cardiac mitochondrial energy production. Expand
Rapid turnover of connexin43 in the adult rat heart.
TLDR
Results indicate that Cx43 turns over rapidly in the adult heart and is degraded by multiple proteolytic pathways, which could play an important role in gap junction remodeling in response to cardiac injury. Expand
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis
TLDR
It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life. Expand
Dephosphorylation and Intracellular Redistribution of Ventricular Connexin43 During Electrical Uncoupling Induced by Ischemia
TLDR
The hypothesis that uncoupling induced by acute ischemia is associated with changes in phosphorylation of the major cardiac gap junction protein, connexin43 (Cx43), is tested and it is suggested that dephosphorylation and translocation of Cx43 from gap junctions into intracellular pools. Expand
Desmosomal Dysfunction due to Mutations in Desmoplakin Causes Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
TLDR
DSP expression in cardiomyocytes is crucial for maintaining cardiac tissue integrity, and DSP abnormalities result in ARVD/C byCardiomyocyte death, changes in lipid metabolism, and defects in cardiac development. Expand
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.
TLDR
It is concluded that, under in vitro conditions, disruption of the Gata-4 gene results in a specific block in visceral endoderm formation in homozygous deficient ES cells, which should yield insights into the regulation of yolk sacEndoderm development and the factors expressed by visceral endODerm that influence differentiation of adjoining ectoderm/mesoderm. Expand
A novel mouse model of lipotoxic cardiomyopathy.
TLDR
It is demonstrated that fatty acid uptake/utilization mismatch in the heart leads to accumulation of lipid species toxic to cardiac myocytes, and a novel mouse model of metabolic cardiomyopathy is established to provide insight into the role of perturbations in myocardial lipid metabolism in the pathogenesis of inherited and acquired forms of heart failure. Expand
A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.
TLDR
Routine immunohistochemical analysis of a conventional endomyocardial-biopsy sample appears to be a highly sensitive and specific diagnostic test for ARVC. Expand
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