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Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina
The recent discovery and characterization of several proteins that purify with endogenous, bound retinoid have given rise to the suggestion that these proteins, which are abundant in retina, performExpand
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Molecular Characterization of a Novel Short-chain Dehydrogenase/Reductase That Reduces All-trans-retinal*
The reduction of all-trans-retinal in photoreceptor outer segments is the first step in the regeneration of bleached visual pigments. We report here the cloning of a dehydrogenase, retSDR1, thatExpand
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Biochemistry of visual pigment regeneration: the Friedenwald lecture.
  • J. Saari
  • Medicine, Biology
  • Investigative ophthalmology & visual science
  • 1 February 2000
Phototransduction and the visual cycle play complementary roles in vertebrate vision. Phototransduction is initiated by the photoisomerization of 11-cis-retinal bound to opsin and ultimately resultsExpand
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Vitamin A metabolism in rod and cone visual cycles.
  • J. Saari
  • Biology, Medicine
  • Annual review of nutrition
  • 18 July 2012
The chromophore of all known visual pigments consists of 11-cis-retinal (derived from either vitamin A1 or A2) or a hydroxylated derivative, bound to a protein (opsin) via a Schiff base. AbsorptionExpand
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Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium.
The endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium have been identified by their spectral characteristics and theirExpand
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High-performance liquid chromatography analysis of visual cycle retinoids.
Publisher Summary Analysis of visual cycle retinoids under various experimental conditions has provided a wealth of information regarding the fundamentals of the visual process. This chapterExpand
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Visual Cycle Impairment in Cellular Retinaldehyde Binding Protein (CRALBP) Knockout Mice Results in Delayed Dark Adaptation
Mutations in the human CRALBP gene cause retinal pathology and delayed dark adaptation. Biochemical studies have not identified the primary physiological function of CRALBP. To resolve this, weExpand
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Zonulae adherentes pore size in the external limiting membrane of the rabbit retina.
The interphotoreceptor space (IPS) of the retina is bordered by the retinal pigment epithelium, photoreceptors, and Müller cells and surrounds the photoreceptor outer and inner segments. It containsExpand
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Multiple Phosphorylation of Rhodopsin and the In Vivo Chemistry Underlying Rod Photoreceptor Dark Adaptation
Dark adaptation requires timely deactivation of phototransduction and efficient regeneration of visual pigment. No previous study has directly compared the kinetics of dark adaptation with rates ofExpand
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Cellular retinaldehyde-binding protein interacts with ERM-binding phosphoprotein 50 in retinal pigment epithelium.
PURPOSE To characterize mechanisms of apical localization of visual cycle components in retinal pigment epithelium (RPE) by the identification of cellular retinaldehyde-binding protein (CRALBP)Expand
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