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Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are
There is strong evidence that adenosine mediates the antiinflammatory effects of MTX in this model of RA, and the findings suggest that abstinence from caffeine, a ubiquitous food additive and medication, may enhance the therapeutic effects ofMTX in RA. Expand
Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).
It is concluded that antagonists of mGlu1 receptors are potential anticonvulsant agents and that activation of m Glu1 receptor probably contributes to a variety of epileptic syndromes. Expand
Mechanistic Insights into the PdII‐Catalyzed Chemoselective N‐Demethylation vs. Cyclometalation Reactivity Pathways in 1‐Aryl‐N,N‐dimethylethanamines
Two structurally isomeric substituted N,N-dimethylethanamines have been prepared. Treatment of the 2,4-di-tert-butylphenyl isomer with PdII ions generated the ortho-metalated complexes. On the otherExpand
Development of a novel chiral palladacycle and its application in asymmetric hydrophosphination reaction.
The enantiomerically pure palladacycle was used to promote the asymmetric hydrophosphination reaction between diphenylphosphine and dimethyl acetylenedicarboxylate and the (31)P{(1)H} NMR spectroscopy indicated that only one stereo-isomeric product was formed. Expand
Synthesis, optical resolution, and stereochemical properties of a rationally designed chiral C–N palladacycle
A novel racemic tertiary amine, 1-(2,5-diisopropylphenyl)-N,N-dimethylethanamine, was synthesized from 2,5-diisopropylbenzaldehyde via a multistep approach in high overall yield. The orthoExpand