• Publications
  • Influence
Mimetics of Hormetic Agents: Stress-Resistance Triggers
  • J. S. Sonneborn
  • Biology, Medicine
    Dose-response : a publication of International…
  • 1 January 2010
TLDR
By elucidating common pathways activated by hormetic agent's mimetics, new strategies for intervention in aging, disease, and trauma emerge and co-activators may be required for expression of the desired physiological conditioning health and rejuvenation benefits.
Hormetic Triggers for Intervention in Aging, Disease and Trauma
TLDR
Con Conserved stress mimetics are highlighted here that rejuvenate DNA and proteins repair and thus may intervene in aging, disease, and trauma.
Exercise-induced stress response as an adaptive tolerance strategy.
TLDR
Both the potential of exercise as a model system of a natural stress inducer and polyubiquitin as a biomarker of stress were established in these studies.
POST-TREATMENT WITH THE NOVEL DELTORPHIN E, A &dgr;2-OPIOID RECEPTOR AGONIST, INCREASES RECOVERY AND SURVIVAL AFTER SEVERE HEMORRHAGIC SHOCK IN BEHAVING RATS
TLDR
Deltorphin E is an effective pharmaceutical intervention in severe hemorrhagic shock and, perhaps, in other ischemic shock scenarios when administered after the onset of stress, and may have clinical potential.
The Myth and Reality of Reversal of Aging by Hormesis
  • J. S. Sonneborn
  • Biology
    Annals of the New York Academy of Sciences
  • 1 December 2005
TLDR
The revision of the earlier evolutionary theory implies that natural selection of genes critical for early survival (life span until reproduction) can also be beneficial for extended longevity in old age, tipping the evolutionary balance in favor of a latent inducible life span extension unless excess stressor challenge exceeds the protection capacity.
Alternative strategy for stress tolerance: opioids.
TLDR
The demonstration of an opioid IPC modulation of the ubiquitin stress pathway found here may be relevant for development of drug intervention in heart attacks and stroke.
Telomerase Biology Associations offer Keys to Cancer and Aging Therapeutics.
TLDR
The multiple TERT (telomerase reverse transcriptase) telomerase subunit's unique associations that regulate cell functions that impact aging, cancer, and therapeutics are summarized.
Alternative strategy for Alzheimer's disease: stress response triggers.
TLDR
An alternative approach to immunotherapy intervention in Alzheimer's Disease is the use of mimetics of stress to upregulate endogenous protective cascades to repair age damage, shift the balance of apoptosis to regeneration to promote delay of onset, and even progression of Alzheimer's disease memory dysfunction.
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