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Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies.
TLDR
The data suggest that triglyceride mimetic prodrugs have potential as a means of enhancing immunotherapy via drug targeting to lymphocytes and lymph nodes through metabolic integration into triglyceride deacylation-reacylation pathways. Expand
The Structure of Integrin α1I Domain in Complex with a Collagen-mimetic Peptide*
TLDR
The structure revealed that the α1I domain undergoes a major conformational change upon binding of the collagen peptide, which suggests a basis for the different binding selectivity observed for theα1I and α2I domains. Expand
Marine isocyanides and related natural products--structure, biosynthesis and ecology.
This review highlights structural and biosynthetic work on a group of nitrogen-functionalised terpenes that are almost exclusively found in marine invertebrates and the animals that feed on them. TheExpand
The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes*
TLDR
The crystal structure of a complex between Escherichia coli DsbA and a peptide with a sequence derived from a substrate was reported and suggested a mechanism by which DSBA can simultaneously show broad specificity for substrates yet exhibit specificity for DsbB. Expand
Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide
TLDR
Tunation and mutational analyses show that Phe5-Phe9, Phe12 and Arg15 in R1 are the most important residues for high affinity binding to AMA1, and these residues interact with two well-defined binding hot spots on AMA1 that are suitable for small molecule targeting. Expand
Folate Biosynthesis – Reappraisal of Old and Novel Targets in the Search for New Antimicrobials
TLDR
Future progress in this key area has the potential to benefit the war against devastating organisms such as drug-resistant Staphylococcus aureus and Plasmodium falciparum. Expand
Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis.
TLDR
All three NmDsbAs are strong oxidases with similar redox potentials; however, they differ from EcDsbA in their ability to be reoxidized by E. coli DsbB. Expand
Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening
Significance In this study, we demonstrate a strategy using a combination of NMR-based binding and functional assays to screen a library of low-molecular-weight compounds known as fragments toExpand
Biosynthetic pathways to isocyanides and isothiocyanates; precursor incorporation studies on terpene metabolites in the tropical marine sponges Amphimedon terpenensis and Axinyssa n.sp.
TLDR
Results show conclusively that isocyanides and isothiocyanates are interconverted in the sponge Axinyssa n.sp, and confirm the central role that thiOCyanate occupies in the terpene metabolism of this sponge. Expand
Virtual screening using a conformationally flexible target protein: models for ligand binding to p38α MAPK
TLDR
Ensembles of up to four receptors of similar conformations were generated, generally giving good or very good performances with high ROC AUCs and good enrichment, and the 1BL7-2EWA ensemble was able to outperform each of its constituent receptors and gave high enrichment factors. Expand
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