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Mechanical Stressing of Integrin Receptors Induces Enhanced Tyrosine Phosphorylation of Cytoskeletally Anchored Proteins*
Physical forces play a fundamental role in the regulation of cell function in many tissues, but little is known about how cells are able to sense mechanical loads and realize signal transduction.Expand
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Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells
Although studies in vivo revealed promising results in bone regeneration after implantation of scaffolds together with osteogenic progenitor cells, basic questions remain how material surfacesExpand
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Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials.
The survival and functioning of a bone biomaterial requires a rapid and stable vascularization after implantation. However, the mechanisms involved in the context of the complex healingExpand
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Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response.
Mechanical loading of cells is of fundamental relevance in physiological processes and induces several functional responses in cells. Integrins, a family of adhesion receptors, which are responsibleExpand
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Adhesiveness of the free surface of a human endometrial monolayer for trophoblast as related to actin cytoskeleton.
Adhesiveness of the apical (free) plasma membrane of uterine epithelial cells for trophoblast is essential for the process of human embryo implantation. As epithelial cells are normally repellent,Expand
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  • Open Access
The Mode of Mechanical Integrin Stressing Controls Intracellular Signaling in Osteoblasts
Following the idea that integrin receptors function as mechanotransducers, we applied defined physical forces to integrins in osteoblastic cells using a magnetic drag force device to show how cellsExpand
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Mechanical induction of beta 1-integrin-mediated calcium signaling in a hepatocyte cell line.
Mechanical stress influences growth, differentiation, and gene expression in a variety of cell types. It is believed that via extracellular matrix the mechanical stimulus is transmitted to integrinExpand
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Control of focal adhesion dynamics by material surface characteristics.
The mechanisms of cell adhesion to the extracellular matrix (ECM) which are of fundamental importance for function, survival, and growth of cells involve the formation of focal adhesions toExpand
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  • Open Access
The influence of surface roughness of titanium on β1- and β3-integrin adhesion and the organization of fibronectin in human osteoblastic cells
Mechanisms of cell adhesion and extracellular matrix formation are primary processes in the interaction with the material surface of an implant which are controlled by integrin receptors. The aim ofExpand
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Effects of selenium supplementation on immune parameters in chronic uraemic patients on haemodialysis.
BACKGROUND The involvement of selenium (Se) in immune response has been increasingly recognized, cell-mediated immunity being principally affected by Se deficiency. Blood Se levels in chronic uraemicExpand
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