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Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function
In zebrafish, morpholino‐mediated knockdown of pink1 function did not cause large alterations in the number of dopaminergic neurons in the ventral diencephalon, but the patterning of these neurons and their projections are perturbed and can be rescued by expression of an exogenous pink1 that is not a target of the morpholinos used. Expand
Glutamate drives the touch response through a rostral loop in the spinal cord of zebrafish embryos
Characterizing connectivity in the spinal cord of zebrafish embryos is not only prerequisite to understanding the development of locomotion, but is also necessary for maximizing the potential ofExpand
Octameric CENP-A Nucleosomes Are Present at Human Centromeres throughout the Cell Cycle
These findings indicate that octameric CENP-A nucleosomes mark the centromeric region to ensure proper epigenetic inheritance and kinetochore assembly. Expand
BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals
The results demonstrate the high degree of functional conservation between zebra fish and mammalian Bcl-2 family proteins, thus validating the zebrafish as a model system to further dissect the molecular mechanisms that regulate apoptosis in future forward genetic and chemical modifier screens. Expand
touché Is Required for Touch-Evoked Generator Potentials within Vertebrate Sensory Neurons
It is suggested that touché is required for generator potentials, and that cutaneous mechanoreceptors with generator possibles are necessary for responsiveness to light touch in zebrafish. Expand
Identification of microtubule growth deceleration and its regulation by conserved and novel proteins
Live imaging of microtubule dynamics in Caenorhabditis elegans muscle cells reveals a novel microtubule behavior characterized by an abrupt change in growth rate, named “microtubule growthExpand
A Hybrid Electrical/Chemical Circuit in the Spinal Cord Generates a Transient Embryonic Motor Behavior
It is proposed that double coiling behavior represents an important transition of the motor network from an electrically coupled spinal cord circuit that produces simple periodic coils to a spinal network driven by descending chemical neurotransmission, which generates more complex behaviors. Expand
Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells.
Novel ubiquitination targets are identified that link UHRF1 to transcriptional regulation and DNA damage response, including PCNA-associated factor 15 (PAF15) and E3 ligase ubiquitin-like PHD and RING finger domain-containing protein 1. Expand
Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems
These experiments explain how the combined action of the two main cell wall synthetic systems builds and maintains rods of different widths and suggest this model may be generalizable to bacteria that elongate via the Rod complex. Expand
A unified multi-kingdom Golden Gate cloning platform
A multi-kingdom (MK) Golden Gate assembly platform for experimental work in species from the kingdoms Fungi, Eubacteria, Protista, Plantae, and Animalia is developed, streamlines the assembly of modular DNA constructs for biological assays across a range of model organisms. Expand