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Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.
Data support that CD14 of epithelial cell origin mediates the LPS induction of an antibiotic peptide gene in TECs, providing evidence for the active participation of epithel cells in the host's local defense response to bacteria. Expand
The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.
A new member of this fusion oncogene family, RET/PTC3, which has been implicated in more cases of solid tumor carcinoma than PTC1 or PTC2 and predominates in radiation-induced thyroid cancer of children, was investigated in this study. Expand
Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells
Observations indicate that a strategy for the induction of peptide-based antimicrobial innate immunity is conserved among evolutionarily diverse organisms. Expand
Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha
These lines of investigations support the hypothesis that inducible expression of endogenous antibiotic peptides by inflammatory mediators characterizes local defense of mammalian mucosal surfaces. Expand
Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection.
Evidence of beta-defensin expression in enteric tissue is provided and that the mRNA encoding a major beta- defensin ofEnteric tissue, EBD, is inducibly expressed in enteri epithelial cells, supporting the proposal that beta-Defensins may contribute to host defense of enteric mucosa. Expand
Phage Bxb1 integrase mediates highly efficient site-specific recombination in mammalian cells.
The use of a codon-optimized Bxb1 integrase in mammalian cells is described for the first time, showing that it is able to catalyze unidirectional recombination between attP and attB sites with high efficiency. Expand
Human Enteric Defensins
  • E. Mallow, Ann Harris, +4 authors C. Bevins
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 23 February 1996
It is suggested that low levels of enteric defensin expression in the fetus may be characteristic of an immaturity of local defense, which is thought to predispose infants born prematurely to infection from intestinal microorganisms. Expand
Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53−/− mice
These studies support a model of human thyroid cancer whereby thyroid epithelium expresses RET/PTC3 protein at early stages of tumor development, followed by the reduction of RET/ PTC3 and loss of p53 function with progressive reduction of Fhit protein expression coincident with malignant progression. Expand
CHD7 Maintains Neural Stem Cell Quiescence and Prevents Premature Stem Cell Depletion in the Adult Hippocampus
Using an inducible knockout mouse model, it is shown that the chromatin remodeling factor chromodomain–helicase‐DNA‐binding protein 7 (CHD7) is essential for maintaining NSC quiescence and identifies the first chromatin‐remodeling factor with a role in N SC quiescent and maintenance. Expand