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Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse.
The dual radiolabeled mAb technique was used to quantify the constitutive and induced expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in theExpand
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Regulation of Murine Intestinal Inflammation by Reactive Metabolites of Oxygen and Nitrogen
Several reports have implicated reactive oxygen and nitrogen metabolites (RONS) in the initiation and/or progression of inflammatory bowel diseases (IBDs). We have investigated the role of three keyExpand
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Molecular Determinants of the Prothrombogenic and Inflammatory Phenotype Assumed by the Postischemic Cerebral Microcirculation
Background and Purpose— Circulating blood cells have been implicated in the pathogenesis of cerebral ischemia/reperfusion (I/R) injury and stroke. The objective of this study was to define theExpand
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Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion
Background and Purpose— Although chemokines have been implicated in cardiovascular diseases, few studies have addressed the role of these inflammatory mediators in ischemic stroke. This study testedExpand
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Leukocyte dependence of platelet adhesion in postcapillary venules.
Reperfusion of ischemic tissues results in development of a proinflammatory, prothrombogenic phenotype, culminating in the recruitment of leukocytes and platelets within postcapillary venules. RecentExpand
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CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon.
BACKGROUND AND AIMS Although the CD40-CD40 ligand (CD40L) signaling pathway has been implicated in the pathogenesis of a variety of diseases, including inflammatory bowel disease, the nature of itsExpand
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The regulation of FasL expression during activation‐induced cell death (AICD)
Activation‐induced cell death (AICD), a Fas ligand (FasL)‐dependent pathway, is important for maintaining T‐cell homeostasis. Interleukin‐2 (IL‐2), an enhancer of AICD, can also enhance FasLExpand
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Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.
Recent clinical trials of the gum resin of Boswellia serrata have shown promising results in patients with ulcerative colitis. The objective of this study was to determine whether a semisyntheticExpand
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Mechanisms of platelet and leukocyte recruitment in experimental colitis.
Both leukocytes and platelets accumulate in the colonic microvasculature during experimental colitis, leading to microvascular dysfunction and tissue injury. The objective of this study was toExpand
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Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease
Background— Platelet activation at sites of vascular injury is essential for hemostasis, but it is also a major pathomechanism underlying ischemic injury. Because anti-inflammatory therapies limitExpand
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