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Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse.
TLDR
These studies indicate that while there are significant quantitative differences in constitutive and induced expression of murine ICAM-1 and VCam-1, the kinetics and dose-response characteristics of the two adhesion molecules to TNF-alpha are qualitatively similar.
Regulation of Murine Intestinal Inflammation by Reactive Metabolites of Oxygen and Nitrogen
TLDR
Both the onset and severity of colitis were significantly attenuated in iNOS−/− and 1400W-treated WT mice, and divergent roles for superoxide and iN OS-derived NO in intestinal inflammation are revealed.
Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence.
TLDR
The results suggest that PAF plays an important role in mediating the adhesive interaction between circulating leukocytes and microvascular endothelium induced by ischemia/reperfusion and that the phospholipid promotes the leukocyte extravasation associated with ischemIA/rePerfusion.
Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats.
TLDR
In hypercholesterolemic rats, treatment with fluvastatin significantly attenuated the leukocyte-adherence responses to PAF and LTB4 as well as theLeukocyte emigration response to LTB 4.
Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion
TLDR
These findings implicate blood cell-derived RANTES in the microvascular, inflammatory, and tissue injury responses of the brain to ischemia and reperfusion.
Leukocyte dependence of platelet adhesion in postcapillary venules.
TLDR
Reperfusion of ischemic tissues results in development of a proinflammatory, prothrombogenic phenotype, culminating in the recruitment of leukocytes and platelets within postcapillary venules of the small intestine after 45-min ischemia and 4-h reperfusion, suggesting that heterotypic blood cell interactions may account for postischemic platelet recruitment.
Molecular Determinants of the Prothrombogenic and Inflammatory Phenotype Assumed by the Postischemic Cerebral Microcirculation
TLDR
It is indicated that I/R promotes the adhesion of both platelets and leukocytes in cerebral venules, with the accumulation of adherent leukocyte–endothelial cell adhesion preceding the recruitment of platelets.
Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.
TLDR
The results indicate that the cerebral microvasculature is rendered vulnerable to thrombus formation in β(s) mice via a neutrophil-dependent mechanism that is associated with an increased formation of and enhanced platelet sensitivity toThrombin.
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.
TLDR
The findings demonstrated an anti-inflammatory effect of sAKBA and indicated that P-selectin-mediated recruitment of inflammatory cells is a major site of action for this novel anti- inflammatory agent.
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