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Natural cycle cryo-thaw transfer may improve pregnancy outcome
TLDR
Hormone replacement in preparation for cryo-thaw transfer of embryos was found to be associated with decreased pregnancy rates in comparison to natural cycle Cryo-Thaw transfer, suggesting that higher estradiol levels during HRT cycle may interfere with the window of implantation. Expand
Assessing ovarian response: antral follicle count versus anti-Müllerian hormone.
TLDR
Evidence leans towards AMH level becoming the gold-standard biomarker to evaluate ovarian reserve and predict ovarian response to stimulation, although both AFC and AMH have good predictive value. Expand
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
TLDR
Single-agent pembrolizumab showed modest activity in patients with ROC and higher PD-L1 expression was correlated with higher response. Expand
Pembrolizumab in patients with programmed death ligand 1-positive advanced ovarian cancer: Analysis of KEYNOTE-028.
TLDR
Pembrolizumab conferred durable antitumor activity with manageable safety and toxicity in patients with advanced PD-L1-positive ovarian cancer and is under further investigation in an ongoing phase II trial, KEYNOTE-100. Expand
Antitumor Activity and Safety of Pembrolizumab in Patients with Advanced Recurrent Ovarian Cancer: Results from the Phase 2 KEYNOTE-100 Study.
TLDR
Single-agent pembrolizumab showed modest activity in patients with ROC and higher PD-L1 expression was correlated with higher response. Expand
Effect of peritoneal fluid from women with endometriosis on implantation in the mouse model.
TLDR
In the mouse, expression of alphavbeta3 and leukemia inhibitory factor peaked at the time of implantation and was reduced by injections of human PF from infertile patients with endometriosis. Expand
The role of peripheral gonadotropin-releasing hormone receptors in female reproduction.
TLDR
The ubiquitous GnRH/GnRH receptor system in human tissues has been shown to have some important physiologic functions, and further research to clarify functions of these peripheral GnRH receptors may lead to discovery of new therapeutic options. Expand
Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?
TLDR
The authors' results demonstrate that in the presence of normal semen parameters, low egg number is not an indication to perform ICSI. Expand
A novel mutation of HOXA13 in a family with hand-foot-genital syndrome and the role of polyalanine expansions in the spectrum of Müllerian fusion anomalies.
TLDR
The cause of uterovaginal septa without hand and foot symptoms differs from true HFGS, and when patients present with septa, it is not necessary to subject them to roentgenograms of the distal limbs or to sequence analysis of HOXA13 unless they show clear signs of the other sequelae characteristic oftrue HFGS. Expand
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: Interim results from the phase 2 KEYNOTE-100 study.
TLDR
It is suggested that pembrolizumab (pembro) has clinical activity in patients with PD-L1+ advanced ovarian cancer with AOC using data from the KEYNOTE-028 study (NCT02054806). Expand
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