J. Ruberte

Publications105
h-index24
Citations1,764
Highly Influential Citations79
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • F. Bosch
  • 151 Publications, 5,130 Citations
  • F. Mingozzi
  • 172 Publications, 13,807 Citations
  • E. Ayuso
  • 37 Publications, 1,288 Citations
  • A. Carretero
  • 58 Publications, 726 Citations
  • Publications
  • Influence
Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy.
For most lysosomal storage diseases (LSDs) affecting the CNS, there is currently no cure. The BBB, which limits the bioavailability of drugs administered systemically, and the short half-life of… Expand
  • 135
  • 12
  • PDF
Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance
During the expansion of fat mass in obesity, vascularization of adipose tissue is insufficient to maintain tissue normoxia. Local hypoxia develops and may result in altered adipokine expression,… Expand
  • 215
  • 10
  • PDF
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.
IGF-1 has been associated with the pathogenesis of diabetic retinopathy, although its role is not fully understood. Here we show that normoglycemic/normoinsulinemic transgenic mice overexpressing… Expand
  • 146
  • 7
  • PDF
The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration
Background To characterize the sequential events that are taking place in retinal neurodegeneration in a murine model of spontaneous type 2 diabetes (db/db mouse). Methods C57BLKsJ-db/db mice were… Expand
  • 81
  • 5
  • PDF
CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome).
Mucopolysaccharidosis type II (MPSII) is an X-linked lysosomal storage disease characterized by severe neurologic and somatic disease caused by deficiency of iduronate-2-sulfatase (IDS), an enzyme… Expand
  • 28
  • 5
  • PDF
Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID
Gene therapy is a promising therapeutic alternative for Lysosomal Storage Disorders (LSD), as it is not necessary to correct the genetic defect in all cells of an organ to achieve therapeutically… Expand
  • 15
  • 4
FGF21 gene therapy as treatment for obesity and insulin resistance
Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently available therapies are not suited for all patients in the heterogeneous obese/T2D population, hence the need for… Expand
  • 54
  • 3
Scavenger function of resident autofluorescent perivascular macrophages and their contribution to the maintenance of the blood-retinal barrier.
PURPOSE The retina contains two distinct populations of monocyte-derived cells: perivascular macrophages, and microglia. The present study was undertaken to evaluate the presence and function in… Expand
  • 49
  • 3
  • PDF
Long-Term Retinal PEDF Overexpression Prevents Neovascularization in a Murine Adult Model of Retinopathy
Neovascularization associated with diabetic retinopathy (DR) and other ocular disorders is a leading cause of visual impairment and adult-onset blindness. Currently available treatments are merely… Expand
  • 51
  • 2
  • PDF
Lymphatic drainage of Listeria inonocytogenes and Indian ink inoculated in the peritoneal cavity of the mouse
The lymphatic drainage of the peritoneal cavity has been investigated by intraperitoneal inoculation of an intracellular bacterium (Listeria monocytogenes) and an inert marker (Indian ink). The… Expand
  • 48
  • 2