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Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage
TLDR
A strain of mice is generated that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1, and it is demonstrated that radial glia, Cajal-Retzius cells, glutamatergic neurons, astrocytes, and oligodendrocytic cells of most pallial structures originate from an EmX1-expressing lineage. Expand
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.
TLDR
Evidence is presented that a mouse deficient in Nkx2.1 function does not form pallidal structures, lacks basal forebrain TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum through the striatum and into the cortex. Expand
Model of autism: increased ratio of excitation/inhibition in key neural systems
TLDR
A model postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems and suggests potential therapeutic interventions. Expand
Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.
TLDR
Mice lacking the homeodomain proteins DLX-1 andDLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neoc cortex. Expand
Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.
TLDR
Evidence is presented that the progenitor and postmitotic cells flanking the pallial/subpallial boundary (PSB) in the embryonic mouse can be subdivided into multiple regions that express unique combinations of transcription factors. Expand
Origins of Cortical Interneuron Subtypes
TLDR
An in vitro assay to assess the developmental potential of subregions of the telencephalic proliferative zone to give rise to neurochemically defined interneuron subgroups suggests that the parvalbumin- and the somatostatin-expressing interneurons appear to derive mainly from the caudal ganglionic eminence of the subcortical Telencephalon. Expand
Delineation of Multiple Subpallial Progenitor Domains by the Combinatorial Expression of Transcriptional Codes
TLDR
This study comprehensively analyzed the expression patterns of several transcription factors in the ventricular zone of the developing subpallium in the mouse to generate a detailed molecular map of the different progenitor domains present in this region. Expand
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
TLDR
Evidence is provided that Nkx2.2 has a primary role in ventral neuronal patterning and has an essential role in interpreting graded Shh signals and selecting neuronal identity. Expand
Cell migration in the forebrain.
TLDR
The cellular and molecular mechanisms underlying each of these types of migrations are reviewed and how emerging concepts in neuronal migration are reshaping the understanding of forebrain development in normal and pathological situations are discussed. Expand
Forebrain gene expression domains and the evolving prosomeric model
TLDR
This work sketches a simplified model, in which the secondary prosencephalon is a complex protosegment not subdivided into prosomeres, which exhibits patterning singularities, and continues to postulate that Prosomeres p1-p3 are the caudal forebrain. Expand
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