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A microbial symbiosis factor prevents intestinal inflammatory disease
Humans are colonized by multitudes of commensal organisms representing members of five of the six kingdoms of life; however, our gastrointestinal tract provides residence to both beneficial andExpand
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The gut microbiota shapes intestinal immune responses during health and disease
Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the hostExpand
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Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
To maintain intestinal health, the immune system must faithfully respond to antigens from pathogenic microbes while limiting reactions to self-molecules. The gastrointestinal tract represents aExpand
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MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.
Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of miR-155 during an autoimmune inflammatoryExpand
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Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors
Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled towardExpand
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Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
MicroRNAs regulate gene expression posttranscriptionally and function within the cells in which they are transcribed. However, recent evidence suggests that microRNAs can be transferred between cellsExpand
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Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers withinExpand
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Defining dysbiosis and its influence on host immunity and disease
Mammalian immune system development depends on instruction from resident commensal microorganisms. Diseases associated with abnormal immune responses towards environmental and self antigens have beenExpand
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miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.
Chronic inflammation is a contributing factor to most life-shortening human diseases. However, the molecular and cellular mechanisms that sustain chronic inflammatory responses remain poorlyExpand
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Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
Bacteriophages are the most abundant members of the microbiota and have the potential to shape gut bacterial communities. Changes to bacteriophage composition are associated with disease, but howExpand
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