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Renal effects of selective cyclooxygenase‐2 inhibition in normotensive salt‐depleted subjects
TLDR
To compare the renal hemodynamic and tubular effects of celecoxib, a selective inhibitor of cyclooxygenase‐2 (COX‐2) to those of naproxen, a nonselective inhibitor of cycling enzymes in salt‐depleted subjects, a comparison study is conducted. Expand
Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
TLDR
It is demonstrated that the first administration of the recommended starting dose of irbesartan induces a greater and longer lasting Ang II receptor blockade than that of valsartan and losartan in normotensive subjects. Expand
Hypercalcaemia and acute renal failure after major burns: An under-diagnosed condition.
TLDR
Determining the ionised Ca rather than the total Ca with albumin correction enables earlier detection of hypercalcaemia and Bisphosphonates are an effective treatment option in controlling severe hypercal Caemia and preventing bone loss. Expand
Angiotensin II Receptor Blockade in Normotensive Subjects A Direct Comparison of Three AT 1 Receptor Antagonists
Use of angiotensin (Ang) II AT 1 receptor antagonists for treatment of hypertension is rapidly increasing, yet direct comparisons of the relative efficacy of antagonists to block theExpand
Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding.
TLDR
The delayed in vivo blockade effect observed for enoltasosartan appears to be due to a high and tight protein binding and a slow dissociation process from the carrier, while the delayed in vitro blockade effect was markedly influenced by the presence of plasma proteins, leading to a decrease in its affinity for the receptor and a slower receptor association rate. Expand
Is a pre‐anaesthetic information form really useful?
TLDR
This single‐blind randomized‐controlled study aimed to determine whether an information form given before the pre‐anaesthetic consultation could improve perceived information, information gain and satisfaction level. Expand
Transient femoral neuropathy after knee ligament reconstruction and nerve stimulator‐guided continuous femoral nerve block: a case series
TLDR
A systematic investigation of neurological lesions even when patients were asymptomatic confirmed that ACL reconstruction was followed by quadriceps amyotrophy in 11 patients; this muscle amyotry may be worsened by a femoral neuropathy. Expand
Pharmacologic profile of UR-7247, an orally active angiotensin II AT1 receptor antagonist, in healthy volunteers. p6.
TLDR
UR-7247 is a long-lasting, well-tolerated AT1 receptor in healthy subjects and has a very long plasma elimination half-life, which may be due to a high but also tight binding to protein binding sites. Expand
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