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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo. Expand
Promotion of trophoblast stem cell proliferation by FGF4.
A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines that exclusively contributed to the trophoplast lineage in vivo in chimeras. Expand
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.
It is shown that early inner cell mass (ICM) at E3.5 is already heterogeneous, and a model is proposed in which the ICM develops as a mosaic of EPI and PE progenitors at E 3.5, dependent on Grb2-Ras-MAP kinase signaling, followed by later segregation of the progenitor into the appropriate cell layers. Expand
Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation
It is shown that the differentiation of TE cells can be mimicked by overexpression of Caudal-related homeobox 2 (Cdx2), which is sufficient to generate proper trophoblast stem (TS) cells and suggests that reciprocal inhibition between lineage-specific transcription factors might be involved in the first differentiation event of mammalian development. Expand
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
- A. Nagy, J. Rossant, R. Nagy, W. Abramow-Newerly, J. Roder
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 September 1993
Fully potent early passage R1 cells and the R1-S3 subclone should be very useful not only for ES cell-based genetic manipulations but also in defining optimal in vitro culture conditions for retaining the initial totipotency of ES cells. Expand
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE. Expand
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development. Expand
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.
- J. Rossant, R. Zirngibl, D. Cado, M. Shago, V. Giguère
- Biology, Medicine
- Genes & development
- 1 August 1991
It is shown that a RA response element (RARE) present in the RAR beta gene can direct specific spatial and temporal expression of an hsplacZ transgene during mouse embryogenesis, suggesting that, in vivo, some of the morphogenetic effects of RA could be mediated through localized transcriptional activity controlled by the various RARs. Expand
Retinoid Signaling Determines Germ Cell Fate in Mice
It is found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis, and precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate. Expand
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
It is proposed that active Tead4 promotes TE development in outside cells, whereas Tead 4 activity is suppressed in inside cells by cell contact- and Lats-mediated inhibition of nuclear Yap localization, and differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation. Expand