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Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody.
TLDR
Results indicate that anti-CD4 monoclonal antibody is a powerful immunosuppressive agent for promoting corneal graft survival and that CD8-positive T-cells alone do not cause rejection of cornesal allografts. Expand
Characteristics of corneal xenograft rejection in a discordant species combination.
TLDR
In the discordant guinea pig-to-rat species combination, donor corneas express xenoantigens; rejection of corneal xenografts stimulates IgM and IgG xenoentibody production; sensitization to xenoantsigens can accelerate corneAL xenografted rejection; and discordant corneals, unlike vascularized organs, are not hyperacutely rejected. Expand
Corneal neovascularization induced by xenografts or chemical cautery. Inhibition by cyclosporin A.
TLDR
CsA effectively retards the growth of new vessels in the cornea after xenotransplantation or chemical cauterization and prolongs xenograft survival, but does not suppress angiogenesis in all systems, because it was ineffective in blocking vessel growth in the subcutaneous DAS. Expand
THE DIFFERENTIAL EFFECTS OF DONOR VERSUS HOST LANGERHANS CELLS IN THE REJECTION OF MHC‐MATCHED CORNEAL ALLOGRAFTS
TLDR
The unique absence of donor-derived Ia+ passenger cells and the avascular graft bed conspire to provide the primary minor H-disparate corneal graft with an immunologic privilege not shared by other organ grafts. Expand
Immunohistochemical analysis of the pathogenesis of posterior polymorphous dystrophy.
TLDR
The hypothesis that the cytokeratin-expressing epithelial-like cells found in corneas with posterior polymorphous dystrophy arise via a metaplastic process in which the phenotype of endothelial cells becomes progressively abnormal is supported. Expand
Histopathologic features of rejecting orthotopic corneal xenografts.
TLDR
Examination of the rejected grafts suggests corneal xenografts may be amenable to standard immunosuppressive regimens, suggesting rejection occurs via mechanisms similar to those seen inCorneal allografteds. Expand
The immunogenic privilege of corneal allografts.
TLDR
The immunologically unique characteristics of the corneal graft conspire with the avascular graft bed to produce an "immunologically privileged" environment that promotes graft survival even if the graft bed is initially free of lymphatic and blood vascular drainage channels. Expand
Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2.
TLDR
Findings in this study are consistent with the possibility that some NAb arise via crossreactivity with microbial antigens and are predominantly directed against carbohydrate rather than protein antIGens, which is a major obstacle to successful transplantation of vascularized xenogeneic organs. Expand
Evidence that the fate of class II-disparate corneal grafts is determined by the timing of class II expression.
TLDR
Immunofluorescent stains demonstrated transient expression of class II antigens on graft epithelium after transplantation, which provides a target for rejection in the preimmunized animals but is of insufficient duration to both prime naive animals and provide atarget for antigraft effectors. Expand
Class I disparate corneal grafts enjoy afferent but not efferent blockade of the immune response.
TLDR
The susceptibility of long term surviving grafts to rejection induced by skin grafts indicates the orthotopic corneal grafts are antigenic but not immunogenic, and if the recipient has previously been exposed to donor antigens, a single Class I disparity is sufficient to provoke rejection of all subsequent corneals. Expand
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