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Fiber Orientation in the Canine Left Ventricle during Diastole and Systole
The wall has a well-ordered distribution of fiber angles varying from about 60° (from the circumferential direction) at the inner surface to about –60° on the outer surface, and the greatest change in angle occurs at the two surfaces (endocardial and epicardial).
Fibulin-5/DANCE is essential for elastogenesis in vivo
It is reported that fibulin-5 (also known as DANCE), a recently discovered integrin ligand, is an essential determinant of elastic fibre organization and may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibre in the skin, lung and vasculature.
ErbB2 is essential in the prevention of dilated cardiomyopathy
Physiological analysis revealed the onset of multiple independent parameters of dilated cardiomyopathy, including chamber dilation, wall thinning and decreased contractility, and suggested ErbB2 signaling inCardiomyocytes is essential for the prevention of Dilated carduomyopathy.
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
In vivo evidence is provided that cav-1 is essential for the control of systemic NO levels and normal cardiopulmonary function and the loss of Cav-1 leads to a dramatic increase in systemic No levels.
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
Evidence is provided that atrial-specific and inducible expression of the atrial natriuretic factor gene can be segregated, suggesting that a distinct set of regulatory cis sequences may mediate the up-regulation of the ANF gene during in vivo pressure overload hypertrophy.
Idiopathic Hypertrophic Subaortic Stenosis: I. A Description of the Disease Based Upon an Analysis of 64 Patients
The finding of a murmur before the age of 1 year in 9 of the 64 patients, and the reports of IHSS in a stillborn baby and in several infants, as well as the association of IhSS with congenital cardiac malformations, all support the concept that the disease may, at least in some instances, be congenital.