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NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens
Data show unequivocally that in this isolate a functional NetB toxin is critical for the ability of C. perfringens to cause NE in chickens, and the netB mutant is the first rationally attenuated strain obtained in an NE-causing isolate ofC. Expand
Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants
The usage of the newer macrolides has increased dramatically over the last few years, which has led to increased exposure of bacterial populations to macrolide resistance, and the nomenclature for these genes has varied and has been inconsistent. Expand
Genome reduction in Leptospira borgpetersenii reflects limited transmission potential
It is concluded that L. borgpetersenii is evolving toward dependence on a strict host-to-host transmission cycle, similar to L. interrogans, a species with minimal genetic decay and that survives extended passage in aquatic environments encountering a mammalian host. Expand
Toxin B is essential for virulence of Clostridium difficile
The construction of isogenic tcdA and tcdB mutants of a virulent C. difficile strain are described and their use in the hamster disease model is used to show that toxin B is a key virulence determinant. Expand
Molecular genetics and pathogenesis of Clostridium perfringens.
  • J. Rood, S. Cole
  • Medicine, Biology
  • Microbiological reviews
  • 1 December 1991
Now that it is possible to freely move genetic information back and forth between C. perfringens and Escherichia coli, it will be possible to apply modern molecular methods to studies on the pathogenesis of C. perfumeens infections. Expand
Virulence genes of Clostridium perfringens.
  • J. Rood
  • Biology, Medicine
  • Annual review of microbiology
  • 1998
Clostridium perfringens causes human gas gangrene and food poisoning as well as several enterotoxemic diseases of animals. The organism is characterized by its ability to produce numerousExpand
Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis
It is suggested that once incorporated into the L. biflexa genome, laterally transferred DNA undergoes minimal rearrangement due to physical restrictions imposed by high gene density and limited presence of transposable elements, in contrast to the genomes of pathogenic Leptospira species undergo frequent rearrangements. Expand
Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens
It is demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens. Expand
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.
Significant differences between the strains include numerous novel mobile elements and genes encoding metabolic capabilities, strain-specific extracellular polysaccharide capsule, sporulation factors, toxins, and other secreted enzymes, providing substantial insight into this medically important bacterial pathogen. Expand
Binary Toxin Production in Clostridium difficile Is Regulated by CdtR, a LytTR Family Response Regulator
These studies have shown for the first time that binary toxin production is subject to strict regulatory control by the response regulator CdtR, which is a member of the LytTR family of response regulators and is related to the AgrA protein from Staphylococcus aureus. Expand