Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.
The main focus of this article is on new synthetic approaches and biosynthetic investigations, most of which were published between 1997 and 2010, but go beyond, e.g. for some biosyntheses all the way back to the 1980s, to provide the necessary context of information.
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.
Modification of post-PKS tailoring steps through combinatorial biosynthesis.
This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases, and covers literature from 1985 to 2002.
An audience response system strategy to improve student motivation, attention, and feedback.
Focused, strategically placed ARS questions throughout lectures may help students maintain attention and stay motivated to learn and allows instructors to adapt lectures to address areas of deficiency.
Angucycline group antibiotics.
Combinatorial biosynthesis of antitumor indolocarbazole compounds.
- C. Sánchez, Lili Zhu, J. Salas
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 11 January 2005
A biological process based on combinatorial biosynthesis for the production of indolocarbazole compounds (or their precursors) in engineered microorganisms as a complementary approach to chemical synthesis is reported.
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces…
- L. Remsing, A. González, J. Rohr
- Biology, ChemistryJournal of the American Chemical Society
- 14 May 2003
The structures of these three compounds confirmed indirectly the proposed role of MtmW in MTM biosynthesis, and the new mithramycin derivatives bear unexpectedly shorter 3-side chains than MTM, presumably caused by nonenzymatic rearrangement or cleavage reactions of the initially formed pentyl side chain with a reactive beta-dicarbonyl functional group.
Arginine-rhamnosylation as new strategy to activate translation elongation factor P.
It is demonstrated that the modification is needed to develop pathogenicity, making EarP and dTDP-L-rhamnose-biosynthesizing enzymes ideal targets for antibiotic development.
Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications…
The new MTM derivative SDK, obtained by targeted gene inactivation of the ketoreductase MtmW catalyzing the last step in MTM biosynthesis, exhibited greater activity as transcriptional inhibitor compared to MTM and repressed transcription of multiple genes implicated in critical aspects of cancer development and progression.
Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin
It is proposed that the glycosyltransferases encoded by mtmGI and mtmGII are responsible for forming and transferring the disaccharide during mithramycin biosynthesis.