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Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
IpaH proteins are E3 ubiquitin ligases delivered by the type III secretion apparatus into host cells upon infection of humans by the Gram-negative pathogen Shigella flexneri. These proteins compriseExpand
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The TOR Kinases Link Nutrient Sensing to Cell Growth*
Rapamycin is an immunosuppressive natural product that inhibits the proliferation of T-cells in response to nutrients and growth factors. Rapamycin binds to the peptidyl-prolyl isomerase FKBP12 andExpand
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The Tor Pathway Regulates Gene Expression by Linking Nutrient Sensing to Histone Acetylation
ABSTRACT The Tor pathway mediates cell growth in response to nutrient availability, in part by inducing ribosomal protein (RP) gene expression via an unknown mechanism. Expression of RP genesExpand
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The Yersinia enterocolitica pYV virulence plasmid contains multiple intrinsic DNA bends which melt at 37 degrees C.
Temperature has a pleiotropic effect on Yersinia enterocolitica gene expression. Temperature-dependent phenotypes include the switching between two type III protein secretion systems, flagellumExpand
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Multiple Signals Regulate GALTranscription in Yeast
ABSTRACT Gal4p activates transcription of the Saccharomyces GALgenes in response to galactose and is phosphorylated during interaction with the RNA polymerase II (Pol II) holoenzyme. OneExpand
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Genome sequence of Shigella flexneri serotype 5a strain M90T Sm.
Bacteria of the genus Shigella are a major cause of death worldwide (L. von Seidlein et al., PLoS Med. 3:e353, 2006). We sequenced the genome of Shigella flexneri strain M90T Sm (serotype 5a) andExpand
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Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase
ABSTRACT IpaH proteins are bacterium-specific E3 enzymes that function as type three secretion system (T3SS) effectors in Salmonella, Shigella, and other Gram-negative bacteria. IpaH enzymes recruitExpand
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TOR Controls Transcriptional and Translational Programs via Sap-Sit4 Protein Phosphatase Signaling Effectors
ABSTRACT The Tor kinases are the targets of the immunosuppressive drug rapamycin and couple nutrient availability to cell growth. In the budding yeast Saccharomyces cerevisiae, the PP2A-relatedExpand
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Thermoregulation in Yersinia enterocolitica is coincident with changes in DNA supercoiling
Yersinia enterocolitica is a facultative intracellular parasite, displaying the ability to grow saprophytically or invade and persist intracellularly in the mammalian reticuloendothelial system. TheExpand
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Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi.
The TOR kinases were first identified in Saccharomyces cerevisiae as the targets of the immunosuppressive drug rapamycin. Subsequent studies employing rapamycin as a tool in yeast have given usExpand
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