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Antineoplastic Activity of Highly Purified Bacterial Glutaminases
More intensive therapy with three extensively purified glutaminase preparations with considerably lower Km values resulted in marked inhibition of an Ehrlich ascites carcinoma and significant increases in the survival time of tumour-bearing animals.
Purification and Properties of a Highly Potent Antitumor Glutaminase-Asparaginase from Pseudomonas 7 A *
- J. Roberts
Crystalline glutaminase-asparaginase which is effective against solid as well as ascites tumors was prepared from soil isolate organism Pseudomonas 7A and is adaptable to large scale production of the enzyme.
In vitro Cytocidal Effect of L-Glutaminase on Leukaemic Lymphocytes
The blood lymphocytes from patients with chronic lymphocytic leukaemia were found to be more sensitive than normal lymphocytes to incubation with 170 mIU of L-asparaginase/ml.
Active enzyme sedimentation of antitumor asparaginase and glutaminase enzymes
Studies on a new glutaminase-asparaginase, therapeutic properties, half-life, and alterations in the plasma amino acids. Abstr.
Glutaminase induced toxicity and anti-glutaminase antibodies in mice. Abstr.