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Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord
Localization of serotonin-4 receptors in the striatonigral pathway in rat brain
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
- R. Altiere, D. C. Travis, J. Roberts, D. Thompson
- Chemistry, BiologyThe Journal of pharmacology and experimental…
- 1 July 1994
In the present study, experiments in isolated pulmonary arteries were undertaken to characterize the muscarinic receptor subtypes mediating the two separate responses by utilizing subtype-selective antagonists and determining pA2 values of the antagonists through Schild analysis.
TR3 death receptor expression in the normal and ischaemic brain
Clearance of Gadolinium from the Brain with No Pathologic Effect after Repeated Administration of Gadodiamide in Healthy Rats: An Analytical and Histologic Study.
Low levels of gadolinium are present in the brain after repeat dosing with gadodiamide, which is partially cleared over 20 weeks with no detectable neurotoxicity.
The motor nerve terminal as the primary focus for drug-in-duced facilitation of neuromuscular transmission.
- W. Riker, J. Roberts, F. Standaert, H. Fujimori
- BiologyThe Journal of pharmacology and experimental…
- 1 November 1957
3-OH PTMA may overcome completely a profound curare paralysis, while a less severe block may be incompletely dissipated by 3-OH PTEA, highlighting the importance of the methonium center as an adjunct in anti-curare action.
Nonuniform Cardiac Sympathetic Nerve Discharge: Mechanism for Coronary Occlusion and Digitalis-Induced Arrhythmia
This study examined nonuniform postganglionic cardiac sympathetic neural discharge as a possible mechanism involved in the production of coronary occlusion or ouabain-induced arrhythmias in cats and found it may alter ventricular excitation and conduction to produce arrhythmia.
The effect of age on adenosine A1 receptor function in the rat heart.
- E. Gao, D. Snyder, M. Johnson, E. Friedman, J. Roberts, J. Horwitz
- BiologyJournal of molecular and cellular cardiology
- 1 February 1997
The data indicate that in addition to the age-related decline in beta-adrenergic receptor function with age, there is also a decrease in adenosine A; receptor-mediated responses, which is specific to the adenoine A1 receptor.
Decreased nuclear factor-κB DNA binding activity following permanent focal cerebral ischaemia in the rat
Reduced adenosine A1 receptor and G alpha protein coupling in rat ventricular myocardium during aging.
The results suggest that the age-related decrease in ventricular A1-AdoR-mediated response is related to a reduction in the coupling between A 1- adenosine A1 receptor and their G proteins.