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CDK inhibitors: positive and negative regulators of G1-phase progression.
This work challenges previous assumptions about how the G1/S transition of the mammalian cell cycle is governed, helps explain some enigmatic features of cell cycle control that also involve the functions of the retinoblastoma protein (Rb) and the INK4 proteins, and changes the thinking about how either p16 loss or overexpression of cyclin D-dependent kinases contribute to cancer. Expand
Inhibitors of mammalian G1 cyclin-dependent kinases.
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Cyclin D2-Cdk4 complexes bind competitively to and down-regulate the activity of p27 and may thereby act in a pathway that reverses Cdk2 inhibition and enables G1 progression. Expand
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
It is found that mammalian cells express two forms of cyclin E protein which differ from each other by the presence or absence of a 15-amino-acid amino-terminal domain, and cyclins E and D1 control two different transitions within the human cell cycle. Expand
Cyclin E-CDK2 is a regulator of p27Kip1.
CDK inhibitors are thought to prevent cell proliferation by negatively regulating cyclin-CDK complexes. We propose that the opposite is also true, that cyclin-CDK complexes in mammmalian cells canExpand
The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network.
The risk of spontaneous preterm delivery is increased in women who are found to have a short cervix by vaginal ultrasonography during pregnancy. Expand
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.
It is reported that the cyclin-dependent kinase inhibitor p27(Kip1) is selectively expressed in the supporting-cell population of the organ of Corti, and may provide an important pathway for inducing hair-cell regeneration in the mammalian hearing organ. Expand
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
It is shown here that cell adhesion and growth factors jointly regulate the cyclin D1- and E- dependent kinases, establishing the cell cycle basis for explaining the combined requirement for growth factors and the extracellular matrix in transit through the Rb checkpoint, entry into S phase, and anchorage-dependent growth. Expand
Preeclampsia: an endothelial cell disorder.
It is proposed that poorly perfused placental tissue releases a factor(s) into the systemic circulation that injuries endothelial cells and set in motion a dysfunctional cascade of coagulation, vasoconstriction, and intravascular fluid redistribution that results in the clinical syndrome of preeclampsia. Expand
[p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex].
It is shown that the cyclin-dependent kinase inhibitor p27Kip1 plays an important role in neurogenesis in the mouse cerebral cortex, by promoting the differentiation and radial migration of cortical projection neurons. Expand