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Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo.
TLDR
This work has identified several NPY analogs that bind the NPY Y(1) receptor with high affinity and exhibit full agonist activity, measured as inhibition of forskolin-stimulated cAMP production in cells expressing the cloned NPy Y( 1) receptor. Expand
Neurotensin binding to extraneural and neural receptors: comparison with biological activity and structure--activity relationships.
TLDR
A highly significant correlation was found between the two binding systems and the biological potencies obtained from the peptide abilities to contract isolated longitudinal smooth muscle strips of the guinea pig ileum when the binding affinities of neurotens in and neurotensin analogs were compared in the extraneural and neural systems. Expand
Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents
TLDR
Data show that obestatin neither influences cumulative food intake, gastric motility or vagal afferent activity nor CCK-induced satiety signaling. Expand
Contraction of major artery segments of rat by fish neuropeptide urotensin II.
TLDR
It is concluded that U II acts on vascular smooth muscle and induces the contraction partly through intracellular Ca2+ mobilization but mainly by stimulating the influx of extracellular Ca 2+ via potential dependent and potential independent calcium channels. Expand
Neurohormones from fish tails. II: Actions of urotensin I in mammals and fishes.
TLDR
This chapter discusses the actions of urotensin I in mammals and fishes and investigates the vascular actions of UI in several mammalian species in order to isolate UI in a highly purified form and to determine its structure in two teleosteans. Expand
Neurohumoral control of ileal electrolyte transport. II. Neurotensin and substance P.
Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: evidence from the use of selective VIP antagonists and VIP antiserum.
  • J. Grider, J. Rivier
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 May 1990
TLDR
The results indicate that VIP (and peptide histidine isoleucine) is the transmitter responsible for neurally induced gastric and intestinal relaxation. Expand
Radioimmunoassays for fish tail neuropeptides: II. Development of a specific and sensitive assay for and the occurrence of immunoreactive urotensin II in the central nervous system and blood of
TLDR
A sensitive radioimmunoassay based on an antiserum to synthetic Gillichthys mirabilis urotensin II generated in rabbits, reacting with all known forms of the UII peptides, was developed and immunoreactive UII was detected in different parts of the brain, spinal cord, and blood of C. commersoni. Expand
Urotensin I, a CRF-like neuropeptide, stimulates acth release from the teleost pituitary.
TLDR
It is demonstrated that urotensin I stimulates ACTH release in the goldfish, which suggests that urotsin I or a urotENSin I-like peptide may serve as a CRF in teleost fishes. Expand
Isolation, Amino‐Acid Sequence, Synthesis and Biological Properties of Urotensin I from Hippoglossoides elassodon
TLDR
A 41‐residue urotensin I neuropeptide was isolated from urophyses of the marine teleost Hippoglossoides elassodon (the flathead sole) and was purified by reversed‐phase high‐performance liquid chromatography. Expand
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