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The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae.
Current knowledge and models for how silenced chromatin in Saccharomyces cerevisiae forms, functions, and is inherited are described and emerging evidence that mutations that cause global changes in the modification of histones can alter the balance between euchromatin and silenced Chromatin within a cell is described. Expand
Global Mapping of the Yeast Genetic Interaction Network
Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms. Expand
A Protein Complex Containing the Conserved Swi2/Snf2-Related ATPase Swr1p Deposits Histone Variant H2A.Z into Euchromatin
- M. Kobor, Shivkumar Venkatasubrahmanyam, +5 authors J. Rine
- Biology, Medicine
- PLoS biology
- 23 March 2004
A novel role for a member of the ATP-dependent chromatin remodeling enzyme family is revealed in determining the region-specific histone subunit composition of chromatin in vivo and controlling the epigenetic state of Chromatin. Expand
Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae.
Evidence for the existence of four SIR genes is presented and some recessive mutations in different genes fail to complement in Saccharomyces cerevisiae, indicating unusual complementation properties for a number of sir mutations. Expand
Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
These data suggested a model of ER protein degradation in which the Hrd1p and Hrd3p proteins conspire to deliver HMG-R to the 26S proteasome, and lend in vivo support to the proposed role of the p97/TRAP-2/Hrd2p protein as a functionally important component of the 25S proteAsome. Expand
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae.
A model for the spreading of silenced chromatin involving cycles of nucleosome deacetylation by Sir2p followed by recruitment of additional Sir2 p, Sir3p, and Sir4p to the newly de acetylated nucleosomes is suggested and generalizable to other types of heritable chromatin states. Expand
Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in Saccharomyces cerevisiae
It is suggested that Saccharomyces cerevisiae and human cells regulate sterol synthesis by different mechanisms. Expand
Telomeric heterochromatin boundaries require NuA4-dependent acetylation of histone variant H2A.Z in Saccharomyces cerevisiae.
Results show a role for H2A.Z acetylation in restricting silent chromatin, and reveal that H2.Z and H4 can contribute to a common function essential to life. Expand
The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus
- Devin R. Scannell, Oliver A. Zill, +6 authors C. T. Hittinger
- Biology, Medicine
- G3: Genes | Genomes | Genetics
- 1 June 2011
Improved genome sequences of three species of Saccharomyces sensu stricto yeasts are presented, enabling a re-examination of the tempo and mode of yeast gene evolution and improved inferences of species-specific gains and losses, and genetically marked, stable haploid strains are generated for all three species. Expand
Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.
- D. Moazed, A. Kistler, A. Axelrod, J. Rine, Alexander D. Johnson
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 18 March 1997
It is proposed that the Sir3 and SIR4 proteins interact only during the assembly of the SIR protein complex at the silencer and that an early step in assembly unmasks the S IR4 protein to allow its association with SIR3. Expand