• Publications
  • Influence
Oxygen carriers ("blood substitutes")--raison d'etre, chemistry, and some physiology.
  • J. Riess
  • Medicine, Chemistry
  • Chemical reviews
  • 20 November 2001
Selected physicochemical aspects of poly- and perfluoroalkylated substances relevant to performance, environment and sustainability-part one.
TLDR
Surprisingly little data (with considerable discrepancies) is accessible on the physicochemical properties of the PFASs under examination, a situation that requires consideration and rectification. Expand
Perfluorocarbon-based Oxygen Delivery
  • J. Riess
  • Chemistry, Medicine
  • Artificial cells, blood substitutes, and…
  • 1 January 2006
TLDR
OxygentTM, a terminally heat-sterilized, injectable 60% w/v PFC emulsion, has been developed and a search for possible interactions between Oxygent and fluids present during cardiopulmonary bypass surgery detected no effect of the emulsion on hemostasis, hemolysis and blood rheology. Expand
Per- and polyfluorinated substances (PFASs): Environmental challenges
Abstract Long-chain perfluoroalkylated acids are persistent in the environment, leading to ubiquitous exposure of biota. They have been listed as very persistent, very bioaccumulative and toxic byExpand
Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals.
TLDR
Using fluorocarbon vapor to extend the persistence of microbubbles in vivo from seconds to minutes, propelled contrast ultrasonography into clinical practice and new objectives include agents that target specific cells for the molecular imaging of disease, and drug and gene delivery, including ultrasound-triggered delivery. Expand
Perfluorocarbons: Life sciences and biomedical uses Dedicated to the memory of Professor Guy Ourisson, a true RENAISSANCE man.
Perfluorocarbons are primarily characterized by outstanding chemical and biological inertness, and intense hydrophobic and lipophobic effects. The latter effects provide a powerful noncovalent,Expand
Fluorocarbon‐Based in vivo Oxygen Transport and Delivery Systems
  • J. Riess
  • Materials Science, Medicine
  • Vox sanguinis
  • 1 December 1991
TLDR
Progress achieved in the preparation and selection of new, better‐defined and faster‐excreted fluorocarbons, and better surfactants, improved emulsions, knowledge of structure/property relationships along with an improved understanding of the physiologic response to their administration have led to a second generation of highly concentrated, fluid and stable injectable oxygen carriers suitable for a broad range of clinical applications. Expand
Chemistry, physical chemistry, and uses of molecular fluorocarbon--hydrocarbon diblocks, triblocks, and related compounds--unique "apolar" components for self-assembled colloid and interface
3.2.1. Linear F-Alkyl/H-Alkyl Diblocks 1720 3.2.2. Unsaturated Diblocks 1721 3.2.3. Branched Diblocks 1722 3.2.4. Diblocks with Heteroatoms 1723 3.2.5. Diblocks with Heavy Halogens 1724 3.3.Expand
Understanding the Fundamentals of Perfluorocarbons and Perfluorocarbon Emulsions Relevant to In Vivo Oxygen Delivery
  • J. Riess
  • Chemistry, Medicine
  • Artificial cells, blood substitutes, and…
  • 1 January 2005
TLDR
OxygentTM, a stable, small-sized emulsion of a slightly lipophilic, rapidly excreted PFC, perfluorooctyl bromide (perflubron), has been engineered and significant oxygen delivery has been established in animal models and through Phase II and III human clinical trials. Expand
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