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Hormonal control of gene expression in the ovary.
- J. Richards
- BiologyEndocrine reviews
- 1 December 1994
The maturation of ovarian follicles involves several sequential stages: initiation, growth, selection, ovulation, and luteinization, where the growing dominant follicle(s) acquires specific functional characteristics that permit it to differentiate to the preovulatory stage and synthesize estradiol.
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
In ovarian granulosa cells, cyclin D2 is specifically induced by FSH via a cyclic-AMP-dependent pathway, indicating that expression of the various D-type cyclins is under control of distinct intracellular signalling pathways.
MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility
Targeted disruption of the kinases ERK1 and ERK2 in mouse granulosa cells provides in vivo evidence that these kinases are necessary for LH-induced oocyte resumption of meiosis, ovulation, and luteinization-related events.
Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor.
- M. Shimada, I. Hernandez-Gonzalez, I. Gonzalez-Robayna, J. Richards
- BiologyMolecular endocrinology
- 1 June 2006
In COCs, AREG not only induced genes that impact matrix formation but also genes involved in steroidogenesis and immune cell-like functions (Pdcd1, Runx1, Cd52), and FSH-mediated induction of Areg mRNA via p38MAPK precedes AREG induction of Ptgs2 mRNA via ERK1/2 precedes were recorded.
Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1.
It is indicated that FSH and estradiol regulate granulosa cell proliferation during the development of preovulatory follicles by increasing levels of cyclin D2 relative to p27Kip1 and that LH terminates follicular growth by down-regulating cycl in D2 concurrent with up-regulation of p27Cip1.
Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent…
- I. Gonzalez-Robayna, A. E. Falender, S. Ochsner, G. Firestone, J. Richards
- Biology, Computer ScienceMolecular endocrinology
- 1 August 2000
Evidence is provided that FSH, forskolin, and 8-bromo-cAMP stimulate phosphorylation of PKB by mechanisms involving PI3-K (LY294002/wortmannin sensitive) not A kinase (H89 insensitive), a pattern of response mimicking that of IGF-I.
Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases.
- R. Robker, D. Russell, L. Espey, J. Lydon, B. O’Malley, J. Richards
- BiologyProceedings of the National Academy of Sciences…
- 25 April 2000
The identification of two regulated proteases in the ovary, together with their abnormal expression in anovulatory PR knockout mice, suggests that each plays a critical role in follicular rupture and represents a major advance in the understanding of the proteolytic events that control ovulation.
Maturation of ovarian follicles: actions and interactions of pituitary and ovarian hormones on follicular cell differentiation.
- J. Richards
- BiologyPhysiological reviews
Processing and Localization of ADAMTS-1 and Proteolytic Cleavage of Versican during Cumulus Matrix Expansion and Ovulation*
- D. Russell, K. H. Doyle, S. Ochsner, J. Sandy, J. Richards
- BiologyJournal of Biological Chemistry
- 24 October 2003
It is suggested that one function of ADAMTS-1 in ovulation is to cleave versican in the expanded COC matrix and that the anovulatory phenotype of PRKO mice is at least partially due to loss of this function.
Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization.
This review summarizes some new aspects of peptide and steroid hormone signaling in the rodent ovary that appear to regulate cumulus expansion and other aspects relating to ovarian embryogenesis and possibly ovulation and luteinization.