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Effect of the size of biodegradable microparticles on drug release: experiment and theory.
Investigation of the effect of the size of biodegradable microparticles (monolithic dispersions) on the release rate of an incorporated drug in a quantitative way revealed that the degradation behavior of the matrix forming polymer was not significantly affected by the sizes of the devices and that autocatalytic effects do not seem to play a major role. Expand
Evidence and characterization of complex coacervates containing plant proteins: application to the microencapsulation of oil droplets
Abstract The potentiality of using vegetal proteins in complex coacervation was studied through zeta potential and turbidity measurements. Two model proteins were tested and compared: a cerealExpand
Conformational modifications of alpha gliadin and globulin proteins upon complex coacervates formation with gum Arabic as studied by Raman microspectroscopy.
The role of electrostatic and non-Coulombic interactions (intermolecular hydrogen bonds) in stabilizing of protein-polysaccharide complexes is discussed in relation with the overall structure and the charge density profile of these two proteins. Expand
Microencapsulation of protein particles within lipids using a novel supercritical fluid process.
It was shown that BSA does not undergo any degradation after SCCO2 treatment under the SC conditions used in the coating process, and has been achieved over a 24 h period from particles coated with Gelucire50-02, which produces a more homogeneous, film-forming coating. Expand
Freeze-Drying of Composite Core-Shell Nanoparticles
The results indicated that the addition of both sugars and surfactant was essential for the good redispersion of freeze-dried nanoparticles displaying hydrophobic (PIBCA) or hydrophilic (PCL-PEG and CNP) surfaces. Expand
Baclofen-loaded microspheres: preparation and efficacy testing in a new rabbit model.
Improve the encapsulation process for industrial application (scale-up), and to set up an animal model to assess the duration of effect of the new formulations of baclofen, which are a very promising approach for enhancing the efficacy and comfort of patients undergoing spasticity treatment. Expand
A supercritical fluid-based coating technology 1: Process considerations
A novel solvent-free particle coating process, based on the solvent properties of supercritical fluids (SCF) is described, which has been applied to bovine serum albumin and sugar granules and was effective, but different morphologies were obtained depending on the coating material used. Expand
Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: in vitro and in vivo evaluation.
Results showed that the burst effect of baclofen was reduced by at least a factor of 2 in vitro, after microsphere dispersion in viscous media, and in vivo, PF-127 gel was found to be the best vehicle to reduce the burstEffect. Expand
1H NMR relaxation studies of protein-polysaccharide mixtures.
NMR water proton relaxation was used to characterize the structure of plant proteins and plant protein-polysaccharide mixtures in aqueous solutions and the phase separation induced under specific conditions seems to promote the translational diffusion of structured water molecules whereas the rotational motion was more restricted. Expand
Water vapour permeability, diffusion and solubility in latex films
Water vapour diffusion D, solubility S and permeability P coefficients have been determined for films obtained from carboxylated styrene-butadiene (SB) copolymer latexes. The experimental method isExpand