• Publications
  • Influence
The Gamification of Learning and Instruction: Game-Based Methods and Strategies for Training and Education
  • J. Rice
  • Computer Science
  • Int. J. Gaming Comput. Mediat. Simulations
  • 1 October 2012
TLDR
Designing Digitally, Inc., a virtual training and 3D environments development company, introduced a simulation devoted to covering the steps involved in typical firefighter training known as REVAS (Rescue, Exposure, Ventilation, Attack, and Salvage). Expand
  • 1,188
  • 193
  • PDF
Assessing Higher Order Thinking in Video Games
TLDR
This article identifies characteristics of highly cognitive virtual interactive environments and offers a detailed index and scoring rubric for teachers and preservice teachers to use when evaluating the tendencies a video game demonstrates toward encouraging higher order thinking in its participants. Expand
  • 90
  • 11
  • PDF
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library. These indol-4-one and indazol-4-one derivedExpand
  • 126
  • 4
  • PDF
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
OBJECTIVE To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenicExpand
  • 108
  • 3
Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.
A chemoproteomics-based drug discovery strategy is presented that utilizes a highly parallel screening platform, encompassing more than 1000 targets, with a focused chemical library prior to targetExpand
  • 69
  • 3
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the discovery of a novel small moleculeExpand
  • 63
  • 1
Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib.
Inhibition of Hsp90 has emerged as a therapeutic strategy to target NSCLC subtypes, which are refractory to epidermal growth factor receptor (EGFR) inhibitor-based treatment. We report on a novelExpand
  • 19
Novel carbazole and acyl-indole antimitotics.
In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied oneExpand
  • 17
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. TheseExpand
  • 8
High content analysis methods enable high throughput nematode discovery screening for viability and movement behavior in a multiplex sample in response to natural product treatment
Monitoring nematode parasite movement and mortality in response to various treatment samples usually involves tedious manual microscopic analysis. High Content Analysis instrumentation enables rapidExpand