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Adenosine receptors in the nervous system: pathophysiological implications
Adenosine is considered as a fine-tuning modulator of neuronal activity, which via subtle effects causes harmonic actions on neuronal activity whenever this homeostasis is disrupted, pathology may be installed and selective receptor antagonism or agonism required. Expand
Inhibition by ATP of Hippocampal Synaptic Transmission Requires Localized Extracellular Catabolism by Ecto-Nucleotidases into Adenosine and Channeling to Adenosine A1 Receptors
The present results indicate that inhibition byextracellular ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases and channeling of the generated adenosine to adenosines A1 receptors. Expand
Caffeine and adenosine.
Targeting approaches that involve ARs will enhance the possibilities to correct brain dysfunctions, via the universally consumed substance that is caffeine. Expand
Adenosine receptors and the central nervous system.
The time has come to determine the role of these receptors in neurological and psychiatric diseases and identify therapies that will alter the outcomes of these diseases, therefore providing a hopeful future for the patients who suffer from these diseases. Expand
Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition
Abstract Adenosine tonically inhibits synaptic transmission through actions at A 1 receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre-… Expand
Adenosine A2 receptor-mediated excitatory actions on the nervous system
The ability of A2 receptors to interact with other receptors for neurotransmitters/neuromodulators, such as dopamine D2 and D2 receptors, adenosine A1 receptors, CGRP receptors, metabotropic glutamate receptors and nicotinic autofacilitatory receptors, expands the range of possibilities used by adenosines to interfere with neuronal function and communication. Expand
THE EFFECTS OF ADENOSINE TRIPHOSPHATE AND ADENOSINE DIPHOSPHATE ON TRANSMISSION AT THE RAT AND FROG NEUROMUSCULAR JUNCTIONS
The potency of ATP was found to be similar to that of adenosine, and the addition of ATP had no further effect, compatible with the idea that ATP acts in the same way asadenosine. Expand
Cross Talk Between A1 and A2A Adenosine Receptors in the Hippocampus and Cortex of Young Adult and Old Rats
Adenosine modulates synaptic transmission by acting on inhibitory A1 and facilitatory A2A receptors, the densities of which are modified in aged animals. We investigated how A2A receptor activation… Expand
Preferential Release of ATP and Its Extracellular Catabolism as a Source of Adenosine upon High‐ but Not Low‐Frequency Stimulation of Rat Hippocampal Slices
- R. Cunha, E. Vizi, J. Ribeiro, A. Sebastião
- Biology, Medicine
- Journal of neurochemistry
- 1 November 1996
There is a simultaneous, but quantitatively different, release of ATP and adenosine from rat hippocampal slices stimulated at frequencies that can induce plasticity phenomena such as LTP (100 Hz) or LTD (5 Hz). Expand
Fine-tuning neuromodulation by adenosine.
The harmonic way adenosine builds its influence at synapses to control neuronal communication is operated through fine-tuning, 'synchronizing' or 'desynchronizing' receptor activation for neuropeptides such as calcitonin gene-related peptide and vasoactive intestinal peptide. Expand