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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
TLDR
Increase in PGC-1alpha levels dramatically protects neural cells in culture from oxidative-stressor-mediated death, providing a potential target for the therapeutic manipulation of these important endogenous toxins. Expand
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
TLDR
The results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin–cAMP axis in liver. Expand
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
TLDR
It is concluded that FOXO1 and PGC-1alpha interact in the execution of a programme of powerful, insulin-regulated gluconeogenesis, which is necessary for survival during prolonged fasting or starvation. Expand
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
TLDR
It is shown here that many cytokines activate the transcriptional PPAR gamma coactivator-1 (PGC-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of PGC-1 protein. Expand
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
TLDR
It is concluded that FOXO1 and PGC-1α interact in the execution of a programme of powerful, insulin-regulated gluconeogenesis, which is necessary for survival during prolonged fasting or starvation and in diabetes mellitus. Expand
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.
TLDR
It is shown here that PGC-1alpha completely loses its ability to activate key genes of gluconeogenesis such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase when HNF4alpha is absent. Expand
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.
TLDR
The data suggest an autofeedback loop whereby the calcium-signaling pathway may result in a stable induction of PGC-1alpha, contributing to the relatively stable nature of muscle fiber-type determination. Expand
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
TLDR
P160 myb binding protein (p160MBP) is a powerful negative regulator of PGC-1alpha function and provide a molecular mechanism for the activation of P GC-1 alpha by p38 MAPK. Expand
An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
TLDR
It is shown that the PGC-1α promoter is regulated by both CaMKIV and CnA activity, implying a unified pathway, integrating key regulators of calcium signaling with the transcriptional switch P GC-1 α, contributing to the relatively stable nature of muscle fiber-type determination. Expand
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
TLDR
It is shown here that PGC-1α completely loses its ability to activate key genes of gluconeogenesis such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase when HNF4α is absent. Expand
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