• Publications
  • Influence
Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma.
The substantial increase in lamination CTV with little change in CTVF suggests that significant alterations in connective and nonconnective tissue components in the laminar region occur in the early stages of glaucomatous damage. Expand
Comparison of clinical and spectral domain optical coherence tomography optic disc margin anatomy.
The termination of Bruch's membrane, border tissue, and the anterior scleral canal opening may constitute the disc margin within the same eye, depending on the border tissue architecture; this anatomy is consistently visualized by SD-OCT. Expand
24-hour IOP telemetry in the nonhuman primate: implant system performance and initial characterization of IOP at multiple timescales.
IOP fluctuates as much as 10 mm Hg from day to day and hour to hour in unrestrained nonhuman primates, which indicates that snapshot IOP measurements may be inadequate to capture the true dynamic character of IOP. Expand
Deformation of the rodent optic nerve head and peripapillary structures during acute intraocular pressure elevation.
Assessment of the effect of acutely elevated intraocular pressure on retinal thickness and optic nerve head (ONH) structure in the rat eye by spectral domain-optical coherence tomography (SD-OCT) found rapid, reversible posterior deformation of the ONH and thinning of the peripapillary retina. Expand
Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps.
PURPOSE High-resolution images of glaucomatous damage to the retinal nerve fiber layer (RNFL) were obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO) and used as a basis forExpand
The Effect of Age on Optic Nerve Axon Counts, SDOCT Scan Quality, and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in Rhesus Monkeys.
RNFLT declines by 4 μm per decade in healthy rhesus monkey eyes, which is approximately three times faster than loss of optic nerve axons, and current models used to predict retinal ganglion cell losses should be reconsidered. Expand
Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes.
These simulations emphasize the importance of developing both high-resolution imaging of the LC microarchitecture and next-generation, deep-scanning OCT techniques to clarify the relationships between IOP-related LC displacement and CTVF-related stress and strain in the LC. Expand
Cupping in the Monkey Optic Nerve Transection Model Consists of Prelaminar Tissue Thinning in the Absence of Posterior Laminar Deformation
Seven weeks following surgical ONT in the monkey eye, ONH cupping involves prelaminar and rim tissue thinning without posterior deformation of the lamina cribrosa. Expand
Compensation method for obtaining accurate, sub-micrometer displacement measurements of immersed specimens using electronic speckle interferometry
The ESPI interferometer and numerical data analysis procedure presented herein provide reliable, accurate, and repeatable measurement of sub-micrometer deformations obtained from pressurization tests of spherically-shaped specimens immersed in aqueous salt solution. Expand
Defects Along Blood Vessels in Glaucoma Suspects and Patients
Holes seen on circumpapillary OCT scans of glaucoma patients and suspects are associated with localglaucomatous damage, as well as with PIRDs associated with high myopia and ERMs. Expand