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Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.
TLDR
It is concluded that CORT action via CR may be involved in a tonic (permissive) influence on brain function with the septohippocampal complex as a primary target. Expand
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.
TLDR
CRF, the urocortins and their receptors form an intricate network in the brain involved in the acute phase as well as the recovery phase of the stress response. Expand
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
TLDR
It is shown that in mice lacking Crhr1, the medulla of the adrenal gland is atrophied and stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone is reduced and the homozygous mutants exhibit increased exploratory activity and reduced anxiety-related behaviour under both basal conditions and following alcohol withdrawal. Expand
Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications.
TLDR
The rat brain contains two receptor systems for corticosterone: the type-I Corticosterone-preferring receptor and the classical type-II glucocorticoid receptor, which was localized almost exclusively in the hippocampus and extended throughout the brain, with the highest levels in the nucleus paraventricularis, nucleus supraopticus. Expand
Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.
TLDR
It is hypothesized that during amitriptyline treatment a rise in limbic MR may be the initial phenomenon in a successively adjusting HPA system, as evidenced by the decreasing plasma hormone concentrations, declining adrenal size, and up-regulation of GR in particular brain regions. Expand
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
TLDR
The data clearly show that limbic Crhr1 modulates anxiety-related behavior and that this effect is independent of HPA system function, and provide evidence for a new role of limbicCrhr1 in neuroendocrine adaptation to stress. Expand
Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.
TLDR
The partial agonistic activities of antihormones in this assay suggest a direct interaction ofAntihormone-receptor complexes with the response elements on the DNA, which contributes to the understanding of antiHormone pharmacology and increases understanding of the role of human mineralocorticoid and glucocortioid receptors in physiological processes during different endocrine states. Expand
Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis.
TLDR
Voluntary exercise results in complex, adaptive changes at various levels within the HPA axis as well as in sympathoadrenomedullary and limbic/neocortical afferent control mechanisms. Expand
Voluntary Exercise Impacts on the Rat Hypothalamic-Pituitary-Adrenocortical Axis Mainly at the Adrenal Level
TLDR
The differential responses in plasma corticosterone levels to different types of stress in the face of comparable responses in ACTH levels underscore the existence of critical regulatory control mechanisms at the level of the adrenal gland. Expand
Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?
TLDR
Since the timecourse of antidepressant actions on corticosteroid receptors follows more closely that of clinical improvement of depression, antidepressants might elevate mood in depressives through their long-term effects on HPA regulation. Expand
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