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Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona
To promote drug delivery to exact sites and cell types, the surface of nanocarriers is functionalized with targeting antibodies or ligands, typically coupled by covalent chemistry. Once theExpand
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The challenges of oral drug delivery via nanocarriers
Abstract The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantlyExpand
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Protein machineries defining pathways of nanocarrier exocytosis and transcytosis.
The transport of nanocarriers through barriers like the gut in a living organism involves the transcytosis of these nanocarriers through the cell layer dividing two compartments. Understanding howExpand
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Efficient Nanofibrous Membranes for Antibacterial Wound Dressing and UV Protection.
Materials with a hierarchical structure often demonstrate superior properties with combined and even synergistic effects of multiple functions. Herein, we report the design of a new class of materialExpand
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Submicrometer-Sized Roughness Suppresses Bacteria Adhesion
Biofilm formation is most commonly combatted with antibiotics or biocides. However, proven toxicity and increasing resistance of bacteria increase the need for alternative strategies to preventExpand
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Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor.
The integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellularExpand
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BNT162b2 induces SARS-CoV-2-neutralising antibodies and T cells in humans
BNT162b2, a lipid nanoparticle (LNP) formulated nucleoside-modified messenger RNA (mRNA) encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) stabilized in theExpand
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Probing the Impedance of a Biological Tissue with PEDOT:PSS-Coated Metal Electrodes: Effect of Electrode Size on Sensing Efficiency.
Electrodes coated with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) have been employed to measure the integrity of cellular barriers. However, a systematic experimental study ofExpand
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Nanovaccine impact on dendritic cells: transcriptome analysis enables new insights into antigen and adjuvant effects.
Aim: For vaccines the combination between an antigen and adjuvants are both crucially important to trigger an effective immune response in dendritic cells. Innovative adjuvants like resiquimod orExpand