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Vibrio cholerae and cholera: out of the water and into the host.
TLDR
This review provides an overview of the current knowledge of both the host- and environment-specific physiological attributes of V. cholerae.
Characterization of Vibrio cholerae O1 El TorgalU and galE Mutants: Influence on Lipopolysaccharide Structure, Colonization, and Biofilm Formation
TLDR
It is found that galU and galE are essential for the formation of a biofilm in a spontaneous phage-resistant rugose variant, suggesting that the synthesis of UDP-galactose via UDP-glucose is necessary for biosynthesis of the exopolysaccharide.
Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation
TLDR
Extracellular DNA is identified and characterized as a component of the Vibrio biofilm matrix and it is shown that extracellularDNA is modulated and controlled by the two ext racellular nucleases Dns and Xds.
A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria
TLDR
The results suggest a new general mechanism of OMV biogenesis based on phospholipid accumulation in the outer leaflet of the outer membrane, which is highly conserved among Gram-negative bacteria, provides a means for regulation, can account for OMV formation under all growth conditions, and might have important pathophysiological roles in vivo.
Lipoprotein e(P4) is essential for hemin uptake by Haemophilus influenzae
TLDR
A DNA fragment cloned from H. influenzae that allows an Escherichia coli hemA mutant to employ exogenous hemin or protoporphyrin IX as sole sources of porphyrIn is cloned and it is demonstrated that hel is essential for growth under aerobic conditions but not under anaerobic conditions.
MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase)
TLDR
MalY is purified to homogeneity and found to be a pyridoxal-5-phosphate-containing enzyme with the enzymatic activity of a beta C-S lyase (cystathionase), necessary for the function of MalY in repressing the maltose system.
In Vivo Transduction with Shiga Toxin 1-Encoding Phage
TLDR
It is demonstrated that lysogens of Shiga toxin-converting phage H-19B give rise to infectious virions within the host gastrointestinal tract.
Antibacterial activity of silver and zinc nanoparticles against Vibrio cholerae and enterotoxic Escherichia coli
TLDR
It is demonstrated that a single oral administration of silver nanoparticles to infant mice colonized with V. cholerae or ETEC significantly reduces the colonization rates of the pathogens by 75- or 100-fold, respectively.
NadN and e (P4) Are Essential for Utilization of NAD and Nicotinamide Mononucleotide but Not Nicotinamide Riboside in Haemophilus influenzae
TLDR
The functions and substrates of these two proteins as they act together in an NAD utilization pathway are described, which indicate that NadN harbors not only NAD pyrophosphatase but also NMN 5'-nucleotidase activity.
Vibrio cholerae Evades Neutrophil Extracellular Traps by the Activity of Two Extracellular Nucleases
TLDR
A first comprehensive characterization of the interplay between neutrophils and V. cholerae is provided along with new evidence that the innate immune response impacts the colonization of V.Cholerae in vivo, which may enhance survival fitness of the pathogen through NET degradation.
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