• Publications
  • Influence
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer
Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells. A nuclear form ofExpand
  • 293
  • 22
Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients.
Because the incidence of pyoderma gangrenosum (PG) is low, no prospective randomized controlled trials and only a few studies with case numbers of more than 15 patients have been published. To dateExpand
  • 337
  • 18
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
BACKGROUND In recent years, the relevance of vitamin D receptor (VDR) gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies. ItExpand
  • 289
  • 15
Solar radiation and human health.
The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression,Expand
  • 79
  • 8
  • PDF
Pyoderma gangrenosum: Clinical presentation and outcome in 18 cases and review of the literature
Background: Pyoderma gangrenosum (PG) is an idiopathic ulcerative neutrophilic inflammatory skin disease characterized by variable clinical presentation and outcome. Because its incidence is low, noExpand
  • 71
  • 7
Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe.
Vitamin D has important benefits in reducing the risk of many conditions and diseases. Those diseases for which the benefits are well supported and that have large economic effects include many typesExpand
  • 153
  • 6
  • PDF
Toward the blood-borne miRNome of human diseases
In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, andExpand
  • 273
  • 6
  • PDF
UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer.
Exposition of the skin with solar ultraviolet radiation (UV) is the main cause of skin cancer development. The consistently increasing incidences of melanocytic and nonmelanocytic skin tumors areExpand
  • 185
  • 6
Vitamin D and the skin: an ancient friend, revisited
Abstract:  Most vertebrates need vitamin D to develop and maintain a healthy mineralized skeleton. However, 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3], the biologically active vitamin D metabolite,Expand
  • 143
  • 6
  • PDF
High-throughput miRNA profiling of human melanoma blood samples
BackgroundMicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysisExpand
  • 136
  • 6