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Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer
Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells. A nuclear form of… Expand
Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients.
- J. Reichrath, G. Bens, A. Bonowitz, W. Tilgen
- Journal of the American Academy of Dermatology
- 1 August 2005
Because the incidence of pyoderma gangrenosum (PG) is low, no prospective randomized controlled trials and only a few studies with case numbers of more than 15 patients have been published. To date… Expand
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
- Kim Köstner, N. Denzer, C. Müller, R. Klein, W. Tilgen, J. Reichrath
- Medicine, Biology
- Anticancer research
- 1 September 2009
BACKGROUND In recent years, the relevance of vitamin D receptor (VDR) gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies. It… Expand
Solar radiation and human health.
The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression,… Expand
Pyoderma gangrenosum: Clinical presentation and outcome in 18 cases and review of the literature
- D. Hasselmann, G. Bens, W. Tilgen, J. Reichrath
- Journal der Deutschen Dermatologischen…
- 1 July 2007
Background: Pyoderma gangrenosum (PG) is an idiopathic ulcerative neutrophilic inflammatory skin disease characterized by variable clinical presentation and outcome. Because its incidence is low, no… Expand
Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe.
- W. Grant, H. Cross, +6 authors A. Zittermann
- Progress in biophysics and molecular biology
- 1 February 2009
Vitamin D has important benefits in reducing the risk of many conditions and diseases. Those diseases for which the benefits are well supported and that have large economic effects include many types… Expand
Toward the blood-borne miRNome of human diseases
In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and… Expand
UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer.
Exposition of the skin with solar ultraviolet radiation (UV) is the main cause of skin cancer development. The consistently increasing incidences of melanocytic and nonmelanocytic skin tumors are… Expand
Vitamin D and the skin: an ancient friend, revisited
- J. Reichrath
- Experimental dermatology
- 1 July 2007
Abstract: Most vertebrates need vitamin D to develop and maintain a healthy mineralized skeleton. However, 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3], the biologically active vitamin D metabolite,… Expand
High-throughput miRNA profiling of human melanoma blood samples
BackgroundMicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis… Expand