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A Novel Peptide Aldehyde with Activity against Human Cytomegalovirus in Two Different in Vivo Models
- O. Weber, J. Reefschlaeger, H. Rübsamen-Waigmann, S. Raddatz, M. Hesseling, D. Häbich
- Biology, ChemistryAntiviral chemistry & chemotherapy
- 1 February 2000
The antiviral activity of PA 8 as a representative of this novel class of inhibitors against HCMV in vivo was clearly demonstrated, ganciclovir only being slightly superior in its in vivo antiviralactivity.
A rapid quantitative method based on motility of bull sperm cells for in vitro toxicity testing of biomaterials.
Efficacy of 5-Vinyl-l-β-D-arabinofuranosyluracil (VaraU) Against Herpes Simplex Virus Type 2 Strains in Cell Cultures and Against Experimental Herpes Encephalitis in Mice: Comparison with Acyclovir…
- J. Reefschlaeger, P. Wutzler, K. Thiel, G. Herrmann
- Medicine, BiologyPharmaceutical Research
- 1 June 1987
Inhibition of HELF cell proliferation by VaraU was less than that by ACV and Na3PFA, resulting in high selectivity indexes of >100 against HSV-2 for Vara U and ACV, and their in vivo efficacy was assessed in a mouse encephalitis model.
5-Hydroxymethyl-2′-deoxyuridine, a normal DNA constituent in certain Bacillus subtilis phages is cytostatic for mammalian cells
The strong effect of the compound on Ehrlich ascites carcinoma cells is not the result of an anomalously high sensitivity of these cells in the culture conditions used, but is a more general phenomenon also found with other cell lines and in vivo.
Treatment of experimental herpes simplex virus type 1 encephalitis in mice with (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil: comparison with bromovinyl-deoxyuridine and…
Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo.
Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents.
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine against different herpes simplex virus strains in cell culture and against experimental herpes encephalitis in mice.
Antiviral activity of Norakin (triperiden) and related anticholinergic antiparkinsonism drugs.
- H. Presber, C. Schroeder, B. Hegenscheid, H. Heider, J. Reefschlaeger, H. Rosenthal
- Medicine, BiologyActa virologica
- 1 November 1984
The drugs were also active against influenza B virus and several representatives of other virus families, e.g. vaccinia, vesicular stomatitis, polio type 1 and herpes simplex type 1 viruses were insensitive to the compounds.
Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.