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In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus.
To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone (SGZ) express markers specific forExpand
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Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.
The dentate gyrus of the hippocampus is one of the few areas of the adult brain that undergoes neurogenesis. In the present study, cells capable of proliferation and neurogenesis were isolated andExpand
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FGF-2-Responsive Neuronal Progenitors Reside in Proliferative and Quiescent Regions of the Adult Rodent Brain
Neurogenesis is restricted to discrete germinal zones within the developing and the adult central nervous systems. With few exceptions, cells that migrate away from these zones and into theExpand
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Isolation, characterization, and use of stem cells from the CNS.
The nervous system of adult mammals, unlike the rest of the organs in the body, has been considered unique in its apparent inability to replace neurons following injury. However, in certain regionsExpand
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Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
NEUROGENESIS continues throughout adulthood in discrete regions. Proliferative zones include the subependymal zone1–4, from where progenitors migrate along the rostral migratory pathway toExpand
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Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus
The adult rat spinal cord contains cells that can proliferate and differentiate into astrocytes and oligodendroglia in situ. Using clonal and subclonal analyses we demonstrate that, in contrast toExpand
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Multipotent progenitor cells in the adult dentate gyrus.
Neurogenesis persists in the adult dentate gyrus of rodents throughout the life of the organism. The factors regulating proliferation, survival, migration, and differentiation of neuronal progenitorsExpand
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FGF-2-Responsive Neural Stem Cell Proliferation Requires CCg, a Novel Autocrine/Paracrine Cofactor
We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stemExpand
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Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells
  • J. Ray, F. Gage
  • Biology, Medicine
  • Molecular and Cellular Neuroscience
  • 1 March 2006
Adult neurogenesis from neural stem/progenitor cells occurs in discrete regions of the central nervous system of all mammals, but the mechanisms regulating endogenous neurogenesis are poorlyExpand
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Proliferation, differentiation, and long-term culture of primary hippocampal neurons.
Primary embryonic hippocampal neurons can develop morphologically and functionally in culture but do not survive more than a few weeks. It has been reported that basic fibroblast growth factor (bFGF)Expand
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